Institution
University of Portsmouth
Education•Portsmouth, Portsmouth, United Kingdom•
About: University of Portsmouth is a education organization based out in Portsmouth, Portsmouth, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 5452 authors who have published 14256 publications receiving 424346 citations. The organization is also known as: Portsmouth and Gosport School of Science and Art & Portsmouth and Gosport School of Science and the Arts.
Topics: Population, Galaxy, Redshift, Context (language use), Computer science
Papers published on a yearly basis
Papers
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TL;DR: There are over 120 types of brain tumor and approximately 45% of primary brain tumors are gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a median survival rate of 14 months.
Abstract: There are over 120 types of brain tumor and approximately 45% of primary brain tumors are gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a median survival rate of 14 months. Despite progress in our knowledge, current therapies are unable to effectively combat primary brain tumors and patient survival remains poor. Tumor metabolism is important to consider in therapeutic approaches and is the focus of numerous research investigations. Lactate dehydrogenase A (LDHA) is a cytosolic enzyme, predominantly involved in anaerobic and aerobic glycolysis (the Warburg effect); however, it has multiple additional functions in non-neoplastic and neoplastic tissues, which are not commonly known or discussed. This review summarizes what is currently known about the function of LDHA and identifies areas that would benefit from further exploration. The current knowledge of the role of LDHA in the brain and its potential as a therapeutic target for brain tumors will also be highlighted. The Warburg effect appears to be universal in tumors, including primary brain tumors, and LDHA (because of its involvement with this process) has been identified as a potential therapeutic target. Currently, there are, however, no suitable LDHA inhibitors available for tumor therapies in the clinic.
375 citations
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TL;DR: In this article, the authors reported the observation of gravitational waves from two compact binary coalescences in LIGO's and Virgo's third observing run with properties consistent with neutron star-black hole (NSBH) binaries.
Abstract: We report the observation of gravitational waves from two compact binary coalescences in LIGO’s and Virgo’s third observing run with properties consistent with neutron star–black hole (NSBH) binaries. The two events are named GW200105_162426 and GW200115_042309, abbreviated as GW200105 and GW200115; the first was observed by LIGO Livingston and Virgo and the second by all three LIGO–Virgo detectors. The source of GW200105 has component masses 8.9−1.5+1.2 and 1.9−0.2+0.3M⊙ , whereas the source of GW200115 has component masses 5.7−2.1+1.8 and 1.5−0.3+0.7M⊙ (all measurements quoted at the 90% credible level). The probability that the secondary’s mass is below the maximal mass of a neutron star is 89%–96% and 87%–98%, respectively, for GW200105 and GW200115, with the ranges arising from different astrophysical assumptions. The source luminosity distances are 280−110+110 and 300−100+150Mpc , respectively. The magnitude of the primary spin of GW200105 is less than 0.23 at the 90% credible level, and its orientation is unconstrained. For GW200115, the primary spin has a negative spin projection onto the orbital angular momentum at 88% probability. We are unable to constrain the spin or tidal deformation of the secondary component for either event. We infer an NSBH merger rate density of 45−33+75Gpc−3yr−1 when assuming that GW200105 and GW200115 are representative of the NSBH population or 130−69+112Gpc−3yr−1 under the assumption of a broader distribution of component masses.
374 citations
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TL;DR: An overview of some of the mathematical models appearing in the literature for use in the glucose-insulin regulatory system in relation to diabetes is given, enhanced with a survey on available software.
374 citations
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Lawrence Berkeley National Laboratory1, University of California, Berkeley2, Carnegie Mellon University3, Yale University4, University of Portsmouth5, New York University6, University of St Andrews7, Harvard University8, Ohio State University9, Max Planck Society10, Brookhaven National Laboratory11, Princeton University12, University of Wisconsin-Madison13, Open University14, Moscow State University15, New Mexico State University16, University of Utah17, Autonomous University of Madrid18, Case Western Reserve University19, Leibniz Institute for Astrophysics Potsdam20, University of Tokyo21, King's College22, Centre national de la recherche scientifique23, Spanish National Research Council24, Ludwig Maximilian University of Munich25, Abastumani Astrophysical Observatory26, Kansas State University27, Pennsylvania State University28, National University of La Plata29, National Scientific and Technical Research Council30, National Autonomous University of Mexico31
TL;DR: The Baryon Oscillation Spectroscopic Survey (BOSS) as discussed by the authors provides the largest survey of galaxy redshifts available to date, in terms of both the number of galaxies measured by a single survey, and the effective cosmological volume covered.
Abstract: The Baryon Oscillation Spectroscopic Survey (BOSS), part of the Sloan Digital Sky Survey (SDSS) III project, has provided the largest survey of galaxy redshifts available to date, in terms of both the number of galaxy redshifts measured by a single survey, and the effective cosmological volume covered. Key to analysing the clustering of these data to provide cosmological measurements is understanding the detailed properties of this sample. Potential issues include variations in the target catalogue caused by changes either in the targeting algorithm or properties of the data used, the pattern of spectroscopic observations, the spatial distribution of targets for which redshifts were not obtained, and variations in the target sky density due to observational systematics. We document here the target selection algorithms used to create the galaxy samples that comprise BOSS. We also present the algorithms used to create large-scale structure catalogues for the final Data Release (DR12) samples and the associated random catalogues that quantify the survey mask. The algorithms are an evolution of those used by the BOSS team to construct catalogues from earlier data, and have been designed to accurately quantify the galaxy sample. The code used, designated MKSAMPLE, is released with this paper.
373 citations
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TL;DR: In this article, the authors derived the covariant nonlinear dynamical equations for the gravitational and matter fields on the brane, and then linearized to find the perturbation equations on the Brane.
Abstract: In Randall-Sundrum-type brane-world cosmologies, the dynamical equations on the three-brane differ from the general relativity equations by terms that carry the effects of embedding and of the free gravitational field in the five-dimensional bulk. Instead of starting from an ansatz for the metric, we derive the covariant nonlinear dynamical equations for the gravitational and matter fields on the brane, and then linearize to find the perturbation equations on the brane. The local energy-momentum corrections are significant only at very high energies. The imprint on the brane of the nonlocal gravitational field in the bulk is more subtle, and we provide a careful decomposition of this effect into nonlocal energy density, flux and anisotropic stress. The nonlocal energy density determines the tidal acceleration in the off-brane direction, and can oppose singularity formation via the generalized Raychaudhuri equation. Unlike the nonlocal energy density and flux, the nonlocal anisotropic stress is not determined by an evolution equation on the brane, reflecting the fact that brane observers cannot in general make predictions from initial data. In particular, isotropy of the cosmic microwave background may no longer guarantee a Friedmann geometry. Adiabatic density perturbations are coupled to perturbations in the nonlocal bulk field, and in general the system is not closed on the brane. But on super- Hubble scales, density perturbations satisfy a decoupled third-order equation, and can be evaluated by brane observers. Tensor perturbations on the brane are suppressed by local bulk effects during inflation, while nonlocal effects can serve as a source or a sink. Vorticity on the brane decays as in general relativity, but nonlocal bulk effects can source the gravito-magnetic field, so that vector perturbations can be generated in the absence of vorticity.
373 citations
Authors
Showing all 5624 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert C. Nichol | 187 | 851 | 162994 |
Gavin Davies | 159 | 2036 | 149835 |
Daniel Thomas | 134 | 846 | 84224 |
Will J. Percival | 129 | 473 | 87752 |
Claudia Maraston | 103 | 362 | 59178 |
I. W. Harry | 98 | 312 | 65338 |
Timothy Clark | 95 | 1137 | 53665 |
Kevin Schawinski | 95 | 376 | 30207 |
Ashley J. Ross | 90 | 248 | 46395 |
Josep Call | 90 | 451 | 34196 |
David A. Wake | 89 | 214 | 46124 |
L. K. Nuttall | 89 | 253 | 54834 |
Stephen Neidle | 89 | 457 | 32417 |
Andrew Lundgren | 88 | 249 | 57347 |
Rita Tojeiro | 87 | 229 | 43140 |