University of Rouen

About: University of Rouen is a education organization based out in Rouen, France. It is known for research contribution in the topics: Population & Receptor. The organization has 7299 authors who have published 13209 publications receiving 313477 citations.

Synthesis and Photophysical Investigation of a Series of Push–Pull Arylvinyldiazine Chromophores

Abstract: A new series of push–pull arylvinyldiazines has been efficiently prepared by aldol condensation between the appropriate methyldiazine and aromatic aldehyde. The optical absorption and emission properties of these chromophores were studied in different solvents and media. These compounds act as polarity sensors with a strong positive emission solvatochromism. This behavior suggests a highly polar emitting state, which is characteristic of compounds that undergo an internal charge transfer upon excitation. These molecules also exhibit halochromic properties and are potential colorimetric and luminescence pH sensors. The second-order nonlinear properties have been investigated for some of the compounds, and large and positive μβ are obtained, in particular, for pyrimidine derivatives.

Intravenous immunoglobulins for steroid-refractory esophageal involvement related to polymyositis and dermatomyositis: a series of 73 patients.

Abstract: Objective To assess the long-term outcome of esophageal complications in the group of patients receiving intravenous immunoglobulins (IVIG) for the treatment of severe steroid-refractory esophageal involvement related to polymyositis/dermatomyositis (PM/DM). Methods We retrospectively reviewed the medical records of 73 patients (39 with PM, 34 with DM) with steroid-resistant esophageal involvement. Esophageal involvement was evaluated by clinical and manometric investigations. Results Seventy-three patients with steroid-refractory esophageal involvement related to PM/DM received IVIG therapy (2 gm/kg monthly). The median interval between PM/DM diagnosis and the onset of esophageal complications was 6 months. The most common clinical manifestations revealing esophageal dysfunction were dysphagia (69.9%), coughing while eating (61.6%), and gastroesophageal reflux into the pharynx and/or mouth (34.2%). Twenty-five patients exhibited life-threatening esophageal complications requiring exclusive enteral feeding; 33 patients (45.2%) with esophageal impairment developed aspiration pneumonia. Sixty patients (82.2%) exhibited resolution of esophageal clinical manifestations, leading to a return to normal oral feeding and ablation of feeding enteral tubes. Four other patients (5.5%) improved, although they still experienced mild dysphagia intermittently. Because of impaired cricopharyngeal muscle relaxation, another patient successfully underwent cricopharyngeal myotomy. Eight patients died from aspiration pneumonia (n = 6) and cancer (n = 2). Muscle weakness, thoracic myopathy, and aspiration pneumonia were independent predictive factors of IVIG-treated esophageal complications in PM/DM patients. Conclusion Our findings indicate that IVIG should be considered in life-threatening esophageal impairment complicating steroid-resistant PM/DM. We also suggest that combined therapy of IVIG and high-dose steroids may be the first-line therapy in PM/DM patients with life-threatening esophageal manifestations.

Enantioselective protonations: fundamental insights and new concepts

Abstract: This review deals with the main results obtained in the field of enantioselective protonations. This method allows easy access to various enantiomerically enriched compounds starting from either the corresponding racemic mixture (deracemization process) or various prochiral precursors. Discussions about different factors governing the stereoselectivity as well as a compilation of literature data are given.

Thermosensitive hollow capsules based on thermoresponsive polyelectrolytes

Abstract: Thermosensitive hollow capsules were successfully fabricated by the layer-by-layer deposition onto colloid particles of oppositely charged diblock copolymers each containing a poly (N-isoproprylacrylamide) (PNIPAM) block and by the subsequent decomposition of the core. The multilayer growth was characterized by electrophoresis and single particle light scattering. By combining confocal microscopy observation and FRAP measurements, we showed that the morphology and the permeability of the capsules change upon heating in aqueous solution. The decrease of size accompanied by a decrease of the permeability with increasing temperature was attributed to structural rearrangements in the shell. However, this process is only partially reversible upon cooling, limiting the thermoresponsive behavior of the capsules.