University of Rouen

TL;DR: It is reported that inactivation of Tet2 in mouse perturbs both early and late steps of hematopoiesis including myeloid and lymphoid differentiation in a cell-autonomous manner, endows the cells with competitive advantage, and eventually leads to the development of malignancies.

TL;DR: In children who are born very preterm, cognitive and neuromotor impairments at 5 years of age increase with decreasing gestational age, and prevention of the learning disabilities associated with cognitive deficiencies in this group is an important goal for modern perinatal care.

TL;DR: Assessment of the immune status via Immunoscore provides a potent indicator of tumor recurrence beyond microsatellite-instability staging that could be an important guide for immunotherapy strategies.

TL;DR: Percutaneous heart valve implantation is feasible in inoperable patients with end-stage AS leading to hemodynamic and clinical improvement, and Continued advances and improved patient selection should decrease adverse events in the near future.