Institution
University of Rouen
Education•Rouen, France•
About: University of Rouen is a education organization based out in Rouen, France. It is known for research contribution in the topics: Population & Receptor. The organization has 7299 authors who have published 13209 publications receiving 313477 citations.
Topics: Population, Receptor, Laser, Atom probe, Membrane
Papers published on a yearly basis
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NorthShore University HealthSystem1, University of British Columbia2, Mayo Clinic3, Henry Ford Health System4, University of California, Los Angeles5, Laval University6, McGill University7, Federal University of São Paulo8, Albany Medical College9, University of Cambridge10, Rabin Medical Center11, St. Francis Medical Center12, University of Toronto13, University of Nebraska Medical Center14, Case Western Reserve University15, Columbia University16, University of Bonn17, University of Rouen18, St Thomas' Hospital19, Henry Ford Hospital20
TL;DR: TMVR with balloon-expandable valves in patients with severe MAC is feasible but may be associated with significant adverse events, and this strategy might be an alternative for selected high-risk patients with limited treatment options.
Abstract: Objectives This study sought to evaluate the outcomes of the early experience of transcatheter mitral valve replacement (TMVR) with balloon-expandable valves in patients with severe mitral annular calcification (MAC) and reports the first large series from a multicenter global registry. Background The risk of surgical mitral valve replacement in patients with severe MAC is high. There are isolated reports of successful TMVR with balloon-expandable valves in this patient population. Methods We performed a multicenter retrospective review of clinical outcomes of patients with severe MAC undergoing TMVR. Results From September 2012 to July of 2015, 64 patients in 32 centers underwent TMVR with compassionate use of balloon-expandable valves. Mean age was 73 ± 13 years, 66% were female, and mean Society of Thoracic Surgeons score was 14.4 ± 9.5%. The mean mitral gradient was 11.45 ± 4.4 mm Hg and the mean mitral area was 1.18 ± 0.5 cm 2 . SAPIEN valves (Edwards Lifesciences, Irvine, California) were used in 7.8%, SAPIEN XT in 59.4%, SAPIEN 3 in 28.1%, and Inovare (Braile Biomedica, Brazil) in 4.7%. Access was transatrial in 15.6%, transapical in 43.8%, and transseptal in 40.6%. Technical success according to Mitral Valve Academic Research Consortium criteria was achieved in 46 (72%) patients, primarily limited by the need for a second valve in 11 (17.2%). Six (9.3%) had left ventricular tract obstruction with hemodynamic compromise. Mean mitral gradient post-procedure was 4 ± 2.2 mm Hg, paravalvular regurgitation was mild or absent in all. Thirty-day all-cause mortality was 29.7% (cardiovascular = 12.5% and noncardiac = 17.2%); 84% of the survivors with follow-up data available were in New York Heart Association functional class I or II at 30 days (n = 25). Conclusions TMVR with balloon-expandable valves in patients with severe MAC is feasible but may be associated with significant adverse events. This strategy might be an alternative for selected high-risk patients with limited treatment options.
251 citations
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TL;DR: In this article, the authors prove the existence and uniqueness of a renormalised solution of the nonlinear problem, where the data f and u0 belong to L1(Ω × (0, T)) and L1 (Ω), and where the function a:(0,T) × Ω × ℝN → ℘N is monotone (but not necessarily strictly monotonous) and defines a bounded coercive continuous operator from the space into its dual space.
Abstract: In this paper we prove the existence and uniqueness of a renormalised solution of the nonlinear problemwhere the data f and u0 belong to L1(Ω × (0, T)) and L1 (Ω), and where the function a:(0, T) × Ω × ℝN → ℝN is monotone (but not necessarily strictly monotone) and defines a bounded coercive continuous operator from the space into its dual space. The renormalised solution is an element of C0 ([ 0, T] L1 (Ω)) such that its truncates TK(u) belong to withthis solution satisfies the equation formally obtained by using in the equation the test function S(u)φ, where φ belongs to and where S belongs to C∞(ℝ) with
249 citations
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TL;DR: Exome sequencing in autosomal dominant early-onset Alzheimer disease (ADEOAD) index cases without mutation on known genes found that in five patients, the SORL1 gene harbored unknown nonsense or missense mutations, suggesting further genetic heterogeneity, involving another gene of the same pathway is present in ADEOAD.
Abstract: Performing exome sequencing in 14 autosomal dominant early-onset Alzheimer disease (ADEOAD) index cases without mutation on known genes (amyloid precursor protein (APP), presenilin1 (PSEN1) and presenilin2 (PSEN2)), we found that in five patients, the SORL1 gene harbored unknown nonsense (n=1) or missense (n=4) mutations. These mutations were not retrieved in 1500 controls of same ethnic origin. In a replication sample, including 15 ADEOAD cases, 2 unknown non-synonymous mutations (1 missense, 1 nonsense) were retrieved, thus yielding to a total of 7/29 unknown mutations in the combined sample. Using in silico predictions, we conclude that these seven private mutations are likely to have a pathogenic effect. SORL1 encodes the Sortilin-related receptor LR11/SorLA, a protein involved in the control of amyloid beta peptide production. Our results suggest that besides the involvement of the APP and PSEN genes, further genetic heterogeneity, involving another gene of the same pathway is present in ADEOAD.
249 citations
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TL;DR: In this paper, it was inferred that citrus peel pectins consist of Homogalacturonans (HGs) strectches of similar lengths, irrespective of the mode of extraction.
249 citations
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University of Rennes1, University of California, Los Angeles2, University of Montpellier3, Université de Montréal4, university of lille5, University of Toulouse6, National and Kapodistrian University of Athens7, University of Bordeaux8, Laval University9, University of Nantes10, University of Rouen11, University of Clermont-Ferrand12, Katholieke Universiteit Leuven13, University of Strasbourg14, Hospital Universitario La Paz15, University Hospital Bonn16
TL;DR: PSM status occurs more frequently in cases in which surgery is imperative and is associated with an increased risk of recurrence, but PSM status does not appear to influence cancer-specific survival.
247 citations
Authors
Showing all 7360 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yves Agid | 141 | 669 | 74441 |
Alexis Brice | 135 | 870 | 83466 |
Mohamed Eddaoudi | 94 | 327 | 64217 |
Hervé Tilly | 86 | 479 | 30321 |
David Cohen | 83 | 635 | 37722 |
Jörg Neugebauer | 81 | 491 | 30909 |
Hubert Vaudry | 80 | 975 | 34350 |
Michel Baudry | 80 | 372 | 23890 |
Richard L. Stevens | 79 | 264 | 19148 |
Claudine Berr | 75 | 297 | 27919 |
Christian P. Robert | 75 | 535 | 36864 |
Thierry Frebourg | 71 | 307 | 22403 |
Georges Pelletier | 69 | 432 | 19018 |
Michel Vert | 69 | 333 | 17899 |
Jean-Charles Schwartz | 69 | 252 | 15917 |