University of Rouen

About: University of Rouen is a education organization based out in Rouen, France. It is known for research contribution in the topics: Population & Receptor. The organization has 7299 authors who have published 13209 publications receiving 313477 citations.

TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy.

Abstract: Recent studies have suggested that activation of the EGFR pathway leads to malignant transformation only if the p53 protein is inactivated. Therefore, we evaluated the impact of TP53 mutations on cetuximab-based chemotherapy (CT) sensitivity in combination with KRAS mutations that have been associated with cetuximab resistance. KRAS and TP53 status were assessed in tumours from 64 metastatic colorectal cancer patients treated with cetuximab-based CT and correlated to clinical response using the Fisher's exact test. Times to progression (TTPs) according to gene status were calculated using the Kaplan–Meier method and compared with log-rank test. TP53 mutations were found in 41 patients and were significantly associated with controlled disease (CD), as defined as complete response, partial response or stable disease (P=0.037) and higher TTP (20 vs 12 weeks, P=0.004). Remarkably, in the subgroup of 46 patients without KRAS mutation, but not in patients with KRAS mutation, TP53 mutations were also associated with CD (P=0.008) and higher TTP (24 vs 12 weeks, P=0.0007). This study suggests that TP53 mutations are predictive of cetuximab sensitivity, particularly in patients without KRAS mutation, and that TP53 genotyping could have a clinical interest to select patients who should benefit from cetuximab-based CT.

Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans

Abstract: Obesity is often associated with increased appetite and food intake, despite normal blood levels of the hunger hormone ghrelin Here the authors show that ghrelin-reactive antibodies in the blood of obese mice and humans enhance the orexigenic effect of ghrelin by protecting it from degradation

Effects of stretch on the local structure of preely propagating premixed low-turbulent flames with various lewis numbers

Abstract: An experimental investigation of the flame response to strain rate in the case of unsteady premixed low-turbulent flames is presented. In order to point out the fundamental aspects of the mutual interaction between combustion and turbulence, measurements of local flame properties (curvature, displacement speed) and tangential strain rate were performed under varying conditions of Lewis number and turbulence. Three different mixtures (methane/air, propane/air, and hydrogen/air) were successively spark ignited in a vertical wind tunnel. The expanding flame freely propagated in a grid-generated decaying turbulent flow. An advanced field imaging technique coupling high-speed laser tomography and cross-correlation particle image velocimetry (PIV) was used to measure the temporal evolution of local flame stretch exerted by the turbulent cold flow. Local flame curvature and local displacement speed were calculated from flame-front contours. Curvature probability density functions (PDFs) were negatively skewed, especially for nonunity Lewis numbers, and displacement speed distributions underlined the influence of local stretch and thermodiffusive effects on flame-speed variations. Tangential strain rate was determined by using the velocity field in the neighborhood of the flame front and appears to be independent of the Lewis numbers. A strong correlation between local flame curvature and tangential strain rate was demonstrated, underlining the cold flow effects on the local flame structure. The influences of turbulence and Lewis number were evaluated and compared with numerical simulations. Then, local flame stretch distributions were determined versus time, indicating that a significant proportion of the flame was under compression.