University of Rouen

About: University of Rouen is a education organization based out in Rouen, France. It is known for research contribution in the topics: Population & Receptor. The organization has 7299 authors who have published 13209 publications receiving 313477 citations.

Morphosedimentary evolution of the macrotidal Seine estuary subjected to human impact

Abstract: Many estuaries in the world have been subjected to significant human impact since the 19th century. Natural infilling and human activities, including building of embankments, dikes and jetties have modified both the morphology of these estuaries and the distribution of sedimentary facies. The Seine, a macrotidal estuary, provides a good opportunity to study such modifications, as the latest morphosedimentary observations could be compared to old sediment maps as well as to geotechnical drilling data. In the mouth of the Seine, originally a sand/gravel system sediment distribution, has now been transformed into a muddy system. The result is a regressive sequence several meters thick. It is typically fining-up and corresponds to a shift from a distal term (pebbles, gravel, and coarse sands) at its base to a proximal term (mud and fine sands) at its top. Civil engineering works have reduced the available amount of space within the estuary, leading to an increase in the natural downstream shift of the depocenter of mud brought by winter river floods. The deposition area of the mud is today in the open marine zone, where waves and tidal currents render the balance of this process precarious.

Influence of microwave irradiation on enzymatic properties: applications in enzyme chemistry

Abstract: Although microwave-assisted reactions are widely applied in various domains of organic chemistry, their use in the area of enzyme chemistry has been rather limited, due to the high temperatures associated with the microwave heating: Because current technology, allows a good control of reaction parameters, several examples of microwave-assisted enzyme chemistry have been reported, using stable and effective biocatalysts (modified enzymes). The purpose of this review is to highlight the applications and studies on the influence of microwave irradiation on enzymatic properties and their application in enzyme chemistry.

Structure and properties of fibres from sea-grass (Zostera marina)

Abstract: This paper presents results from a study of fibres extracted from Zostera marina eel-grass collected from the Baltic coast. This species of sea-grass is shown to contain small diameter (around 5 μm) fibres composed of ∼57% cellulose, ∼38% of non-cellulosic polysaccharides (mainly xylan) and ∼5% of residual matter so-called Klason lignin. This composition is quite different to that of commonly used terrestrial fibres. Single fibre stiffness values up to 28 GPa were measured. This stiffness combined with a low density could provide an attractive reinforcement for composite materials, and may be particularly suitable for use in bio-degradable structures.

Brain calcification process and phenotypes according to age and sex: Lessons from SLC20A2, PDGFB, and PDGFRB mutation carriers

Abstract: Primary Familial Brain Calcification (PFBC) is a dominantly inherited cerebral microvascular calcifying disorder with diverse neuropsychiatric expression. Three causative genes have been identified: SLC20A2, PDGFRB and, recently, PDGFB, whose associated phenotype has not yet been extensively studied. We included in the largest published case series of genetically confirmed PFBC, 19 PDGFB (including three new mutations), 24 SLC20A2 (including 4 new mutations), and 14 PDGFRB mutation carriers, from two countries (France and Brazil). We studied clinical features and applied our visual rating scale on all 49 available CT scans. Among the symptomatic mutation carriers (33/57, 58%), the three most frequently observed categories of clinical features were psychiatric signs (72.7%, 76.5%, and 80% for PDGFB, SLC20A2, and PDGFRB, respectively), movement disorders (45.5%, 76.5%, and 40%), and cognitive impairment (54.6%, 64.7%, and 40%). The median age of clinical onset was 31 years, 25% had an early onset (before 18) and 25% a later onset (after 53). Patients with an early clinical onset exhibited mostly isolated psychiatric or cognitive signs, while patients with a later onset exhibited mostly movement disorders, especially in association with other clinical features. CT scans rating allowed identifying four patterns of calcification. The total calcification score was best predicted by the combined effects of gene (SLC20A2 > PDGFB > PDGFRB mutations), sex (male), and (increasing) age, defining three risk classes, which correlated with the four patterns of calcification. These calcification patterns could reflect the natural history of the calcifying process, with distinct risk classes characterized by different age at onset or rate of progression.