Institution
University of Rouen
Education•Rouen, France•
About: University of Rouen is a education organization based out in Rouen, France. It is known for research contribution in the topics: Population & Receptor. The organization has 7299 authors who have published 13209 publications receiving 313477 citations.
Topics: Population, Receptor, Laser, Atom probe, Membrane
Papers published on a yearly basis
Papers
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TL;DR: Non-invasive ventilation might be associated with an increased risk of intubation and mortality and should be used cautiously in immunocompromised patients with acute hypoxaemic respiratory failure.
168 citations
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TL;DR: This article addresses the online exact string matching problem which consists in finding all occurrences of a given pattern p in a text t and presents experimental results in order to bring order among the dozens of articles published in this area.
Abstract: This article addresses the online exact string matching problem which consists in finding all occurrences of a given pattern p in a text t. It is an extensively studied problem in computer science, mainly due to its direct applications to such diverse areas as text, image and signal processing, speech analysis and recognition, information retrieval, data compression, computational biology and chemistry.In the last decade more than 50 new algorithms have been proposed for the problem, which add up to a wide set of (almost 40) algorithms presented before 2000. In this article we review the string matching algorithms presented in the last decade and present experimental results in order to bring order among the dozens of articles published in this area.
167 citations
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University of Guelph1, Dalhousie University2, Natural Resources Canada3, California Academy of Sciences4, Cornell University5, University of Pennsylvania6, University of New Brunswick7, Sewanee: The University of the South8, Chinese Academy of Sciences9, Harvard University10, York University11, Natural History Museum12, Imperial College London13, University of California, Santa Barbara14, University of Rouen15, University of Illinois at Urbana–Champaign16, Agriculture and Agri-Food Canada17, Beijing Genomics Institute18
TL;DR: It is concluded that regular assays for Wolbachia presence and type can, and should, be adopted by large scale insect barcoding initiatives and the ability to query this DNA library for endosymbionts is one of the ancillary benefits of such a large scale endeavor.
Abstract: Wolbachia is a genus of bacterial endosymbionts that impacts the breeding systems of their hosts. Wolbachia can confuse the patterns of mitochondrial variation, including DNA barcodes, because it influences the pathways through which mitochondria are inherited. We examined the extent to which these endosymbionts are detected in routine DNA barcoding, assessed their impact upon the insect sequence divergence and identification accuracy, and considered the variation present in Wolbachia COI. Using both standard PCR assays (Wolbachia surface coding protein – wsp), and bacterial COI fragments we found evidence of Wolbachia in insect total genomic extracts created for DNA barcoding library construction. When >2 million insect COI trace files were examined on the Barcode of Life Datasystem (BOLD) Wolbachia COI was present in 0.16% of the cases. It is possible to generate Wolbachia COI using standard insect primers; however, that amplicon was never confused with the COI of the host. Wolbachia alleles recovered were predominantly Supergroup A and were broadly distributed geographically and phylogenetically. We conclude that the presence of the Wolbachia DNA in total genomic extracts made from insects is unlikely to compromise the accuracy of the DNA barcode library; in fact, the ability to query this DNA library (the database and the extracts) for endosymbionts is one of the ancillary benefits of such a large scale endeavor – for which we provide several examples. It is our conclusion that regular assays for Wolbachia presence and type can, and should, be adopted by large scale insect barcoding initiatives. While COI is one of the five multi-locus sequence typing (MLST) genes used for categorizing Wolbachia, there is limited overlap with the eukaryotic DNA barcode region.
166 citations
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TL;DR: In this paper, the photoinitiated polymerization of dimethacrylate oligomer with 2,2-dimethyl-2-hydroxy acetophenone (Darocur 1173) as radical photo-initiator was studied by using isothermal photocalorimetry.
166 citations
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University of Sydney1, University of Toronto2, University of Michigan3, Washington State University4, University of Helsinki5, University of Western Australia6, Harvard University7, Scripps Research Institute8, French Institute of Health and Medical Research9, Broad Institute10, University of Arizona11, Pierre-and-Marie-Curie University12, Royal Children's Hospital13, University of Pennsylvania14, Medical College of Wisconsin15, University of Gothenburg16, Université catholique de Louvain17, Autonomous University of Madrid18, University of Rouen19, VU University Amsterdam20, National Institutes of Health21, Tokyo Medical University22, University of Melbourne23
TL;DR: It is demonstrated that mutations in the gene encoding L MOD3 underlie congenital myopathy and demonstrate that LMOD3 is essential for the organization of sarcomeric thin filaments in skeletal muscle.
Abstract: Nemaline myopathy (NM) is a genetic muscle disorder characterized by muscle dysfunction and electron-dense protein accumulations (nemaline bodies) in myofibers. Pathogenic mutations have been described in 9 genes to date, but the genetic basis remains unknown in many cases. Here, using an approach that combined whole-exome sequencing (WES) and Sanger sequencing, we identified homozygous or compound heterozygous variants in LMOD3 in 21 patients from 14 families with severe, usually lethal, NM. LMOD3 encodes leiomodin-3 (LMOD3), a 65-kDa protein expressed in skeletal and cardiac muscle. LMOD3 was expressed from early stages of muscle differentiation; localized to actin thin filaments, with enrichment near the pointed ends; and had strong actin filament-nucleating activity. Loss of LMOD3 in patient muscle resulted in shortening and disorganization of thin filaments. Knockdown of lmod3 in zebrafish replicated NM-associated functional and pathological phenotypes. Together, these findings indicate that mutations in the gene encoding LMOD3 underlie congenital myopathy and demonstrate that LMOD3 is essential for the organization of sarcomeric thin filaments in skeletal muscle.
166 citations
Authors
Showing all 7360 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yves Agid | 141 | 669 | 74441 |
Alexis Brice | 135 | 870 | 83466 |
Mohamed Eddaoudi | 94 | 327 | 64217 |
Hervé Tilly | 86 | 479 | 30321 |
David Cohen | 83 | 635 | 37722 |
Jörg Neugebauer | 81 | 491 | 30909 |
Hubert Vaudry | 80 | 975 | 34350 |
Michel Baudry | 80 | 372 | 23890 |
Richard L. Stevens | 79 | 264 | 19148 |
Claudine Berr | 75 | 297 | 27919 |
Christian P. Robert | 75 | 535 | 36864 |
Thierry Frebourg | 71 | 307 | 22403 |
Georges Pelletier | 69 | 432 | 19018 |
Michel Vert | 69 | 333 | 17899 |
Jean-Charles Schwartz | 69 | 252 | 15917 |