Institution
University of Rouen
Education•Rouen, France•
About: University of Rouen is a education organization based out in Rouen, France. It is known for research contribution in the topics: Population & Receptor. The organization has 7299 authors who have published 13209 publications receiving 313477 citations.
Topics: Population, Receptor, Laser, Atom probe, Membrane
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that a two [4Fe-4S]-cluster radical S-adenosyl-L-methionine (SAM) enzyme converts L-amino acids into their D-counterparts by catalysing Cα-hydrogen-atom abstraction and using a critical cysteine residue as the hydrogen-atom donor.
Abstract: Ribosomally synthesized peptides are built out of L-amino acids, whereas D-amino acids are generally the hallmark of non-ribosomal synthetic processes. Here we show that the model bacterium Bacillus subtilis is able to produce a novel type of ribosomally synthesized and post-translationally modified peptide that contains D-amino acids, and which we propose to call epipeptides. We demonstrate that a two [4Fe-4S]-cluster radical S-adenosyl-L-methionine (SAM) enzyme converts L-amino acids into their D-counterparts by catalysing Cα-hydrogen-atom abstraction and using a critical cysteine residue as the hydrogen-atom donor. Unexpectedly, these D-amino acid residues proved to be essential for the activity of a peptide that induces the expression of LiaRS, a major component of the bacterial cell envelope stress-response system. Present in B. subtilis and in several members of the human microbiome, these epipeptides and radical SAM epimerases broaden the landscape of peptidyl structures accessible to living organisms.
80 citations
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TL;DR: In this article, a detailed review of the physics basis for the DTE2 operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of DTE plasmas (thermal and particle transport, high confinement mode, Be and W erosion, fuel recovery, etc).
Abstract: For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des.
82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T,
leading up to 2020 and the first experiments with 50%/50% D–T mixtures since 1997 and the
first ever D–T plasmas with the ITER mix of plasma-facing component materials. For this
purpose, a concerted physics and technology programme was launched with a view to prepare
the D–T campaign (DTE2). This paper addresses the key elements developed by the JET
programme directly contributing to the D–T preparation. This intense preparation includes
the review of the physics basis for the D–T operational scenarios, including the fusion power
predictions through first principle and integrated modelling, and the impact of isotopes in the
operation and physics of D–T plasmas (thermal and particle transport, high confinement mode
(H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving
several aspects of plasma operation for DTE2, such as real time control schemes, heat load
control, disruption avoidance and a mitigation system (including the installation of a new
shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the threeions
scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode
antennas, neutral gauges, radiation hard imaging systems…) and the calibration of the JET
neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation
of JET for the 2020 D–T campaign provides an incomparable source of information and a
basis for the future D–T operation of ITER, and it is also foreseen that a large number of key
physics issues will be addressed in support of burning plasmas.
79 citations
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TL;DR: A French open‐label multicenter randomized study to evaluate the effect of high doses of epoetin beta (EPO‐β) during the first 2 weeks of renal transplantation on renal function in patients at risk for delayed graft function (DGF).
79 citations
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TL;DR: Findings strongly suggest the presence of two different neuronal systems reacting with antibodies to α-MSH, as well as a fragment of the common precursor of ACTH and β-lipotropin, which was performed in rat brain.
79 citations
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TL;DR: The number of fetal cases strongly suggests that VACTERL-H association related with rhombencephalosynapsis emerges as a non-random association, and recurrence and consanguinity were noted in two different families, which argue for a sporadic or inherited cause.
Abstract: Rhombencephalosynapsis is an uncommon cerebellar malformation defined by vermian agenesis with fusion of the hemispheres and of the dentate nuclei. Embryologic and genetic mechanisms are still unknown, and to date, no animal models are available. Ultrasound diagnosis is generally suspected after 22 weeks of gestation, and usually the abnormality is suggested by ventriculomegaly. Morphological analysis of 40 fetuses after medical termination of pregnancy allowed us to confirm that rhombencephalosynapsis was always associated with other brain abnormalities or malformations: Purkinje cell heterotopias, fusion of colliculi, forking and/or atresia of the aqueduct and of the third ventricle resulting in a fusion of the thalami, agenesis of the corpus callosum, lobar holoprosencephaly and neural tube defects. Pons and medulla were very infrequently abnormal. Furthermore, complete autopsy made it possible to separate either pure neurologic phenotypes, or associated with extraneural anomalies from syndromic forms: Gomez-Lopez-Hernandez syndrome (1 case) and VACTERL-H syndrome (6 cases). The number of our fetal cases strongly suggests that VACTERL-H association related with rhombencephalosynapsis emerges as a non-random association. Furthermore, recurrence and consanguinity were noted in two different families, which argue for a sporadic or inherited cause. From our results, it could be suggested that rhombencephalosynapsis may be due to defective genes regulating formation of the roof plate and the development of midline cerebellar primordium at the junction of the mesencephalon and of the first rhombomere.
79 citations
Authors
Showing all 7360 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yves Agid | 141 | 669 | 74441 |
Alexis Brice | 135 | 870 | 83466 |
Mohamed Eddaoudi | 94 | 327 | 64217 |
Hervé Tilly | 86 | 479 | 30321 |
David Cohen | 83 | 635 | 37722 |
Jörg Neugebauer | 81 | 491 | 30909 |
Hubert Vaudry | 80 | 975 | 34350 |
Michel Baudry | 80 | 372 | 23890 |
Richard L. Stevens | 79 | 264 | 19148 |
Claudine Berr | 75 | 297 | 27919 |
Christian P. Robert | 75 | 535 | 36864 |
Thierry Frebourg | 71 | 307 | 22403 |
Georges Pelletier | 69 | 432 | 19018 |
Michel Vert | 69 | 333 | 17899 |
Jean-Charles Schwartz | 69 | 252 | 15917 |