Showing papers in "European Journal of Pharmaceutics and Biopharmaceutics in 1999"

TL;DR: This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery and potential medical applications, especially in cancer chemotherapy, are described and discussed.

TL;DR: Stabilization of physically critical SLN dispersions seems possible by inhibition of the transformation of the lipid to the stable modification to cause a distinct increase in the recrystallization index.

TL;DR: The results show that this dry coating method is applicable to the preparation of enteric-coated beads and tablets using commercially available lab-scale apparatus.

TL;DR: The study confirms the satisfactory coating potential of the hot-melt fluid-bed coating process on large spherules or granules with Compritol 888, and several competing mechanisms are also involved, including a diffusion-controlled process and a dissolution mechanism.

TL;DR: When applied to vitamin B2 tablets, Eudragit L 100-55, Opadry enteric (PVAP) and Aqoat (HPMCAS) proved to be quite stable aqueous enteric coatings, whereas cellulose acetate phthalate CAP or cellulOSE acetate trimellitate CAT coatings as ammonia-neutralized aQueous solution or as water-based pseudolatex Aquateric were unstable when stored under stress conditions.

TL;DR: The results show that TMC is able to open the tight junctions of intestinal epithelial cells to allow for paracellular transport of hydrophilic molecules and it is concluded that the charge density of TMC, as determined by the degree of quaternization, is an important factor determining its potential use as an absorption enhancer across intestinal epithelia.

TL;DR: The kinetics of drug release from chitosan microspheres were best fitted by models originally developed for systems in which release rate is largely governed by rate of diffusion through the matrix.

TL;DR: It was found that both manufacturing techniques had to be considered, although the extruded implants degraded more rapidly in vitro than the injection-molded ones, and crystalline network was not destroyed after both manufacturing methods.

TL;DR: The dissolution data indicate that drug release can be modified by changing the degree of crystallinity of MCC, and suggest that the crystal region and the amorphous region in MCC particles may be mainly fractured and deformed plastically during compression, respectively.

TL;DR: The results suggest that oxidized dextran could be an interesting means to cross-link gelatin microspheres allowing the use of this delivery formulation for controlled release of drugs.

TL;DR: General considerations concerning the stability of coated dosage forms are discussed, in order to avoid predictable interactions which may cause long-term stability problems.

TL;DR: The combination of the two polymers, PAA and PVP, could be advantageous for the treatment of the dry eye using PAA based low viscous formulations with polyvinylpyrrolidone (PVP) as 2nd polymer.

TL;DR: Results are used to explain the different drug release mechanisms of the coated pellets and to enable the prediction and optimization of drug release-rates from coated pellets.

TL;DR: The objective was to investigate several factors (composition of the coating formulation, the type and pH of the release medium and curing conditions), which influence the drug release from beads coated with either the aqueous ethylcellulose dispersion, Aquacoat or an organic ethyl cellulose solution.

TL;DR: An increase in the percentage and viscosity grade of HPMC, in the extended release layer, leads to a decrease in the drug delivery rate and produces a wide range of different release rates from only a few hours up to 24 h.

TL;DR: Particle size of mineral oil (hydrocarbons)-in-water emulsions was independent of the HLB of an optimized emulsifier blend, whereas, the particle size of olive oil (triglycerides-in- water emulsion was the smallest at the optimum H LB of the emulsifiers blend.

TL;DR: The objective was to determine the tackiness of acrylic and cellulosic polymer films in order to make predictions on the tackness (agglomeration) of coated dosage forms during coating and curing.

TL;DR: The ability to atomize aqueous-based nanocrystalline colloidal dispersions represents an environmentally sound alternative to the current chlorofluorocarbon (CFC)-based products and may avoid the technical difficulties of reformulating with chlorine-free propellants.

TL;DR: Results confirm that polymer possessing a hydrophobic anchor at its end, like PVA-R, is a suitable material for modifying the surface of doxorubicin-loaded liposomes to improve their stability in the circulating blood.

TL;DR: Drug release studies showed a marked increase in paracetamol dissolution rate when prepared as a solid dispersion, with behaviour consistent with carrier controlled dissolution observed at low drug contents which was ascribed to enhanced dissolution of the drug into the diffusion layer of the PEG 4000.

TL;DR: The aim of the study was to select a dissolution test method for carbamazepine (CBZ) immediate release tablets, giving the best in vitro/in vivo correlations (IVIVC) and to determine the potential of this method as an estimate for bioequivalence testing.

TL;DR: In this review, the experimental devices and procedures used to quantitate polymer adhesion are addressed and the affects of the physical and chemical properties of the substrate, including surface roughness and tablet hydrophobicity, on adhesion of a polymer to either tablets or capsules are discussed.

TL;DR: A mathematical model was derived, which shows that even at high plasmid concentration, small sized polyplexes were formed at low pH and ionic strength, especially when the solution contains 20% (w/v) sucrose.

TL;DR: The dissolution rate, the toxicity and the release from chewing gum of miconazole and econazole cyclodextrin products and complexes and physical mixtures did not give supersaturation and were not as toxic as the above-mentioned compounds.

TL;DR: The presented procedure provides the formulation scientist with a tool to set storage conditions for amorphous drugs and glassy pharmaceutical products.

TL;DR: Results obtained with mercury porosimetry give information on the behaviour of powder and granule particles in granulation or compression, whereas nitrogen adsorption brings out the changes in intraparticular structure of particles.

TL;DR: Scanning electron microscopy pictures showed that for MCC a smooth surface of the tablets resulted, tablets made from kappa-carrageenan showed less 'fusion' and thus more mechanical interlocking is responsible for their stability, and this change in release is in accordance with a change in swelling of tablets made of the binary mixtures.

TL;DR: Optimization based on genetic algorithm showed that using HPMC at 20%, with two roller-compaction passes would produce mechanically acceptable acetaminophene tablets, and PEG and carbopol would also produce acceptable tablets perhaps more suitable for sustained release applications.

TL;DR: Cationic copolymer nanoparticles containing 30% (w/w) methylaminoethyl-methacrylate (MMAEMC) were found to be optimal with regard to biocompatibility and carrier properties for hydrophilic anionic antisense oligonucleotides.

TL;DR: Calcium-induced alginate gel beads containing chitosan salt (Alg-CS) was prepared using nicotinic acid (NA), a drug for hyperlipidemia, and its two functions in gastrointestinal tract were investigated, finding an approximately linear relationship between them.