Showing papers in "Journal of Crohn's and Colitis in 2014"

TL;DR: These guidelines are intended to give practical (whenever possible evidence-based) answers to (pediatric) gastroenterologists who take care of children and adolescents with CD, since many different clinical scenario exist requiring treatment strategies not covered by or different from these guidelines.

TL;DR: It is suggested that FMT is a safe, but variably efficacious treatment for IBD and more randomized controlled trials are needed and should investigate frequency of FMT administration, donor selection and standardization of microbiome analysis.

TL;DR: The results of this survey can be used in defining strategic priorities and planning projects and awareness raising activities, and the unmet needs of IBD patients can be better demonstrated and communicated to the public, health service managers and politicians.

TL;DR: IBD disease burden is lower in ethnic minorities compared to non-Hispanic Whites, however, IBD-related hospitalizations and deaths seem disproportionately high in Non-Hispanic Blacks.

TL;DR: The objective was to better understand the pathophysiological mechanisms of intestinal fibrosis, to identify useful markers and imaging modalities of fibrosis in order to assess its presence and progression, and, finally, to point out possible approaches for the prevention and the treatment of Fibrosis.

TL;DR: It is currently recommended that all women with IBD, particularly those receiving immunosuppressants, strictly adhere to a screening program of cervical surveillance and undergo vaccination against HPV, when appropriate.

TL;DR: There is some evidence that use of NCB-02 enema may tend to result in greater improvements in disease activity compared to placebo in patients with mild-to-moderate distal UC.

TL;DR: Differences in epidemiology, clinical characteristics, and natural history of paediatric and elderly-onset inflammatory bowel disease based on studies performed in general population are described.

TL;DR: A 61-year-old male with Crohn's disease compromising jejunum and terminal ileum managed with mesalamine, azathioprine and infliximab presents a tortuous evolution based on multiple episodes of active CD, acute diverticulitis, Clostridium difficile infection (CDI) and bacteremia for multidrug-sensitive Escherichia coli (MDSEC)

TL;DR: The history of IBD is reviewed, considering the ever-evolving understanding of both UC and CD - the story of a chronic, incurable disease that defies the best efforts to treat it.

TL;DR: The risk of TE is increased in patients with IBD, but there is an increased risk of both ischemic heart disease and mesenteric ischemia.

TL;DR: Subcutaneous ustekinumab is an effective therapeutic option in this challenging patient cohort of severe anti-TNF resistant CD patients and the initial response was successfully maintained in the majority of patients for up to 12months.

TL;DR: A detailed literature review was conducted on epidemiology, risk factors, pathophysiology, chemoprevention and outcomes of colorectal cancer (CRC) in IBD as part of the 3rd ECCO scientific pathogenesis workshop.

TL;DR: Treating beyond symptoms will require a clear management plan influenced by disease severity at presentation, clinical and biological prognostic factors, achievement and maintenance ofclinical and biological remission and pharmacoeconomics.

TL;DR: HRQOL of adult CD patients is consistently determined by markers of active disease, including work disability, increased disease activity, number of relapses, biological treatment and hospitalization rate, which remains a need for additional, possibly modifiable, determinants.

TL;DR: FC seems to increase and remain elevated before clinical or endoscopic relapse, suggesting that it can be used as a surrogate marker for predicting and identifying patients requiring close follow-up in clinical practice.

TL;DR: The incidence of Crohn's disease in a region of Sweden is one of the highest reported in Europe and long symptom duration precedes stricturing or penetrating behaviour which is an independent risk factor for surgery.

TL;DR: More severe UC disease was associated with poorer QoL and greater health care costs and impairment in work productivity and daily activities, and patients in remission had the least work and activity impairment.

TL;DR: The future of classifying, prognosticating and managing IBD involves an outcomes-based approach to identify biomarkers reflecting various biological processes that can be matched with clinically important endpoints.

TL;DR: A web survey was developed to evaluate the awareness of biosimilar mAb among IBD specialists and their readiness to use these therapies, and the most relevant aspects on biosimilars.

TL;DR: The data suggest that there is no benefit in the use of E. coli Nissle as an add-on treatment to conventional therapies for active ulcerative colitis and treatment without a previous antibiotic cure resulted in fewer patients reaching clinical remission.

TL;DR: Incidence rates, disease phenotype and initial treatment characteristics in the 2011 ECCO-EpiCom cohort were not significantly different from that reported in the 2010 cohort.

TL;DR: Abdominal ultrasonography is a useful and reliable technique for the assessment of the endoscopic response to treatment with immunomodulators and/or biological drugs in Crohn's disease and is a highly accurate technique for evaluating the healing of the intestinal mucosa.

TL;DR: Treatment options include oral prolonged courses of metronidazole and systemic immunosuppressive therapy such as corticosteroids and azathioprine, with promising data published on the efficacy of infliximab.

TL;DR: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differing in environmental factors prior to diagnosis exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle.

TL;DR: Preoperative steroids are associated with higher risk of postoperative sepsis and VTE in IBD, and increased infectious control measures and V TE prophylaxis may reduce adverse events.

TL;DR: It is suggested that MCT may be useful in the management of IBD patients with either functional abdominal symptoms or high perceived stress levels but larger studies are required to confirm this.

TL;DR: Combination therapy with ADA and immunomodulator was mildly superior to ADA monotherapy for induction of remission in CD and the rate of remission at 1 year and the need for dose escalation were similar in both groups.

TL;DR: A set of core QIs of structure, process, and outcomes for defining and evaluating an ICCU are identified that may be useful for evaluating and certifying ICCUs.

TL;DR: The findings of this indirect treatment comparison meta-analysis suggest that both infliximab and adalimumab are superior to placebo in the treatment of moderate to moderately severe ulcerative colitis.