Journal ArticleDOI
A ubiquitous family of repeated DNA sequences in the human genome.
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TLDR
It is found that at least half of the 300-nucleotide duplex regions in inverted repeated sequences also have a cleavage site for the restriction enzyme Alu I, implying that the interspersion pattern of repeated and single copy sequences in human DNA is largely dominated by one family of repeated sequences.About:
This article is published in Journal of Molecular Biology.The article was published on 1979-08-15. It has received 362 citations till now. The article focuses on the topics: Repeated sequence & Restriction site.read more
Citations
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Journal ArticleDOI
Alu repeats and human genomic diversity
TL;DR: During the past 65 million years, Alu elements have propagated to more than one million copies in primate genomes, which has resulted in the generation of a series of Alu subfamilies of different ages.
Book ChapterDOI
Highly repeated sequences in mammalian genomes.
TL;DR: This chapter discusses the structure and organization of mammalian, highly repeated sequences at the molecular level with a description of tandemly repeated sequences, that are, satellites, and the segments that are interspersed among other genomic DNA sequences.
Journal ArticleDOI
Alu sequences are processed 7SL RNA genes
TL;DR: It is suggested that mammalian Alu sequences were derived from 7SL RNA (or DNA) by a deletion of the central 7SL-specific sequence, and are therefore processed 7SLRNA genes.
Journal ArticleDOI
Base sequence studies of 300 nucleotide renatured repeated human DNA clones
TL;DR: The nucleotide sequences of 15 clones constructed from these 300 nucleotide S 1 -resistant repeats are determined and ten of these cloned sequences are members of the Alu family of interspersed repeats, a dimeric structure that was evidently formed from a head to tail duplication of an ancestral monomeric sequence.
Journal ArticleDOI
The Alu family of dispersed repetitive sequences
Carl W. Schmid,Warren R. Jelinek +1 more
TL;DR: Property of this repeat sequence, its flanking sequences in chromosomal DNA, and RNA's transcribed from it suggest that it may be a mobile DNA element inserted at hundreds of thousands of different chromosomal locations.
References
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Journal ArticleDOI
Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels.
TL;DR: Electrophoresis in alkaline gels can provide accurate molecular weights for linear, single-Stranded DNAs, and should be useful in analyzing DNA for single-strand breaks, depurinations or topological differences such as ring forms.
Journal ArticleDOI
Kinetics of renaturation of DNA.
James G. Wetmur,Norman Davidson +1 more
TL;DR: It is proposed that the mechanism of the reaction involves the joining of short, homologous sites on the two strands followed by a fast, reversible zippering reaction with forward rate constant kt, which explains the temperature and the GC dependence.
Journal ArticleDOI
Organization, transcription, and regulation in the animal genome.
Eric H. Davidson,Roy J. Britten +1 more
TL;DR: Recent experimental information in areas of animal cell molecular biology which are relevant to the mechanism of gene regulation are concerned, with particular reference to the frequency of structural gene sequences, mRNA turnover, and the interpretation of dipteran complementation groups.
Journal ArticleDOI
Reduction in the rate of DNA reassociation by sequence divergence
TL;DR: An estimate is made of the effect of imperfectly complementary sequences on the rate of reassociation of DNA, which appears to be reduced by a factor of two for each 10 deg.
Journal ArticleDOI
General interspersion of repetitive with non-repetitive sequence elements in the DNA of Xenopus.
TL;DR: A high degree of order exists in the arrangement of DNA sequences in the Xenopus genome, and a little more than 50% of the genome consists of closely interspersed repetitive and non-repetitive sequences.
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