Journal ArticleDOI
Advanced glycation endproducts in food and their effects on health.
Malene W. Poulsen,Rikke Susanne Vingborg Hedegaard,Jeanette M. Andersen,Barbora de Courten,Barbora de Courten,Susanne Bügel,John Nielsen,Leif H. Skibsted,Lars O. Dragsted +8 more
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TLDR
The current review points out several research needs in order to address important questions on AGEs in foods and health.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-10-01. It has received 540 citations till now. The article focuses on the topics: 3-Deoxyglucosone.read more
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Advanced glycation end products, protein crosslinks and post translational modifications in pork subjected to different heat treatments.
TL;DR: Glycation and deamidation formation were tracked in meat proteins through peptidomics to highlight residue level changes that might affect nutrient value in processed muscle based foods.
Journal ArticleDOI
DJ-1 family Maillard deglycases prevent acrylamide formation.
TL;DR: Maillard deglycases constitute a unique enzymatic method to prevent acrylamide formation in food without depleting the components (asparagine and sugars) responsible for its formation.
Journal ArticleDOI
Effects of oxidised linoleic acid on the formation of Nε‐carboxymethyl‐lysine and Nε‐carboxyethyl‐lysine in Maillard reaction system
Ligang Yu,Zhiyong He,Maomao Zeng,Zong-Ping Zheng,Jialiang He,Jialiang He,Mengle Wang,Jie Chen +7 more
TL;DR: In this paper, the effects of oxidised linoleic acid (18:2) on Ne-carboxymethyl-lysine (CML) and Ne-Carboxyethyl -lysine(CEL) formation in Maillard reaction systems were investigated.
Journal ArticleDOI
Short-term effects of dietary advanced glycation end products in rats.
Malene W. Poulsen,Jeanette M. Andersen,Rikke Susanne Vingborg Hedegaard,Andreas N. Madsen,Britta N. Krath,Rastislav Monošík,Monika Judyta Bak,John Nielsen,Birgitte Holst,Leif H. Skibsted,Lesli H. Larsen,Lars O. Dragsted +11 more
TL;DR: RAGE and AGER1 expression can be influenced by a high AGE diet after only 2 weeks in proportion to MG-H1 excretion, and there was no difference in insulin sensitivity, F2-isoprostaglandins, food intake, water intake, body weight or body composition between the groups.
Journal ArticleDOI
Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans.
Ryan Perkins,Edwin R. Miranda,Kristian Karstoft,Paul J. Beisswenger,Thomas P. J. Solomon,Jacob M. Haus +5 more
TL;DR: It is suggested that individuals who are obese but otherwise healthy have the capacity to prevent accumulation of OX and AGEs during metabolic stress by increasing fractional excretion and renal clearance.
References
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Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
TL;DR: Findings indicate that the "diabetes epidemic" will continue even if levels of obesity remain constant, and given the increasing prevalence of obesity, it is likely that these figures provide an underestimate of future diabetes prevalence.
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Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
TL;DR: This report supports earlier predictions of the epidemic nature of diabetes in the world during the first quarter of the 21st century and provides a provisional picture of the characteristics of the diabetes epidemic.
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National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
Goodarz Danaei,Mariel M. Finucane,Yuan Lu,Gitanjali M Singh,Melanie J. Cowan,Christopher J. Paciorek,Christopher J. Paciorek,John K Lin,Farshad Farzadfar,Young-Ho Khang,Gretchen A Stevens,Mayuree Rao,Mohammed K. Ali,Leanne M Riley,Carolyn Robinson,Majid Ezzati +15 more
TL;DR: Glycaemia and diabetes are rising globally, driven both by population growth and ageing and by increasing age-specific prevalences, and effective preventive interventions are needed, and health systems should prepare to detect and manage diabetes and its sequelae.
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Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
John W. Baynes,S R Thorpe +1 more
TL;DR: In this article, the authors investigated whether increased oxidative stress has a primary role in the pathogenesis of diabetic complications or whether it is a secondary indicator of end-stage tissue damage in diabetes.