Journal ArticleDOI
Advanced glycation endproducts in food and their effects on health.
Malene W. Poulsen,Rikke Susanne Vingborg Hedegaard,Jeanette M. Andersen,Barbora de Courten,Barbora de Courten,Susanne Bügel,John Nielsen,Leif H. Skibsted,Lars O. Dragsted +8 more
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The current review points out several research needs in order to address important questions on AGEs in foods and health.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-10-01. It has received 540 citations till now. The article focuses on the topics: 3-Deoxyglucosone.read more
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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
TL;DR: A review will highlight the involvement of AGEs in the development and progression of T2DM and their role in diabetic complications and the role of oxidative stress in hyperglycemia-induced tissue injury.
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Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease ☆
TL;DR: Molecular mechanisms that link obesity, diabetes and AD, including oxidative stress, mitochondrial dysfunction, and inflammation that are observed in these disorders are discussed.
Journal ArticleDOI
Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms.
TL;DR: The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus, and understanding the pathogenic mechanisms of AGEs is paramount to develop strategies against diabetic and cardiovascular complications.
Journal ArticleDOI
A synopsis on aging-Theories, mechanisms and future prospects
João Pinto da Costa,Rui Vitorino,Gustavo M. Silva,Christine Vogel,Armando C. Duarte,Teresa Rocha-Santos +5 more
TL;DR: Some of the most relevant changes that take place during aging are explored and an integrative approach that couples aging research with systems biology, capable of providing novel insights into how and why the authors age, is necessary.
Journal ArticleDOI
Dietary Advanced Glycation End Products and Their Role in Health and Disease
Jaime Uribarri,María Dolores del Castillo,María Pía de la Maza,Rosana Filip,Alejandro Gugliucci,Claudia Luevano-Contreras,Maciste H. Macías-Cervantes,Deborah Helena Markowicz Bastos,Alejandra Medrano,Teresita Menini,Manuel Portero-Otin,Armando Rojas,Geni Rodrigues Sampaio,Kazimierz Wrobel,Katarzyna Wrobel,Ma. Eugenia Garay-Sevilla +15 more
TL;DR: This review illustrates currently known facts about dietary AGEs as well as pointing out areas that require further research.
References
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Journal ArticleDOI
Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice.
Melpomeni Peppa,Harold Brem,Paul Ehrlich,Jian-Gang Zhang,Weijing Cai,Zhu Li,Anca Croitoru,Swan N. Thung,Helen Vlassara +8 more
TL;DR: Increased diet-derived AGE intake may be a significant retardant of wound closure in diabetic mice; dietary AGE restriction may improve impaired diabetic wound healing.
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Advanced Glycation End Products Are Direct Modulators of β-Cell Function
Melinda T. Coughlan,Felicia Y. T. Yap,David C. K. Tong,Sofianos Andrikopoulos,Anna Gasser,Vicki Thallas-Bonke,Diane Webster,Jun-ichi Miyazaki,Thomas W.H. Kay,Robyn Maree Slattery,David M. Kaye,Brian G. Drew,Bronwyn A. Kingwell,Spiros Fourlanos,Per-Henrik Groop,Per-Henrik Groop,Leonard C. Harrison,Mikael Knip,Josephine M. Forbes,Josephine M. Forbes +19 more
TL;DR: It is demonstrated that AGEs directly cause insulin secretory defects, most likely by impairing mitochondrial function, which may contribute to the development of T1D.
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Single Oral Challenge by Advanced Glycation End Products Acutely Impairs Endothelial Function in Diabetic and Nondiabetic Subjects
Jaime Uribarri,Alin Stirban,Denise Sander,Weijing Cai,M. Negrean,Cristina E. Buenting,Theodore Koschinsky,Helen Vlassara +7 more
TL;DR: In this paper, the acute effects of dietary advanced glycation end products (AGEs) on endothelial function of diabetic and nondiabetic subjects were evaluated before and after a single oral AGE challenge (∼1.8 × 10 6 AGE units) in 44 diabetic and 10 non-diabetic subjects.
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Studies on the formation of furosine and pyridosine during acid hydrolysis of different Amadori products of lysine
TL;DR: In this article, the behavior of different lysine Amadori compounds during acid hydrolysis was investigated in order to determine the molar yield of furosine and the other hydrolyisation products.
Journal ArticleDOI
Diets rich in Maillard reaction products affect protein digestibility in adolescent males aged 11–14 y
Isabel Seiquer,José Díaz-Alguacil,Cristina Delgado-Andrade,Magdalena López-Frías,Antonio Muñoz Hoyos,Gabriel Galdó,María Pilar Navarro +6 more
TL;DR: The consumption of a diet rich in MRPs negatively affects protein digestibility in adolescent males aged 11-14 y, and the possible effects of an excessive intake of MRPs during adolescence warrant attention.