Journal ArticleDOI
Advanced glycation endproducts in food and their effects on health.
Malene W. Poulsen,Rikke Susanne Vingborg Hedegaard,Jeanette M. Andersen,Barbora de Courten,Barbora de Courten,Susanne Bügel,John Nielsen,Leif H. Skibsted,Lars O. Dragsted +8 more
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The current review points out several research needs in order to address important questions on AGEs in foods and health.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-10-01. It has received 540 citations till now. The article focuses on the topics: 3-Deoxyglucosone.read more
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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
TL;DR: A review will highlight the involvement of AGEs in the development and progression of T2DM and their role in diabetic complications and the role of oxidative stress in hyperglycemia-induced tissue injury.
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Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease ☆
TL;DR: Molecular mechanisms that link obesity, diabetes and AD, including oxidative stress, mitochondrial dysfunction, and inflammation that are observed in these disorders are discussed.
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Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms.
TL;DR: The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus, and understanding the pathogenic mechanisms of AGEs is paramount to develop strategies against diabetic and cardiovascular complications.
Journal ArticleDOI
A synopsis on aging-Theories, mechanisms and future prospects
João Pinto da Costa,Rui Vitorino,Gustavo M. Silva,Christine Vogel,Armando C. Duarte,Teresa Rocha-Santos +5 more
TL;DR: Some of the most relevant changes that take place during aging are explored and an integrative approach that couples aging research with systems biology, capable of providing novel insights into how and why the authors age, is necessary.
Journal ArticleDOI
Dietary Advanced Glycation End Products and Their Role in Health and Disease
Jaime Uribarri,María Dolores del Castillo,María Pía de la Maza,Rosana Filip,Alejandro Gugliucci,Claudia Luevano-Contreras,Maciste H. Macías-Cervantes,Deborah Helena Markowicz Bastos,Alejandra Medrano,Teresita Menini,Manuel Portero-Otin,Armando Rojas,Geni Rodrigues Sampaio,Kazimierz Wrobel,Katarzyna Wrobel,Ma. Eugenia Garay-Sevilla +15 more
TL;DR: This review illustrates currently known facts about dietary AGEs as well as pointing out areas that require further research.
References
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Improved Insulin Sensitivity Is Associated With Restricted Intake of Dietary Glycoxidation Products in the db/db Mouse
Susanna M. Hofmann,H. Henry Dong,Zhu Li,Weijing Cai,Jennifer Altomonte,Swan N. Thung,Feng Zeng,Edward A. Fisher,Helen Vlassara +8 more
TL;DR: It is demonstrated that reduced AGE intake leads to lower levels of circulating AGE and to improved insulin sensitivity in db/db mice, and LAD-fed mice presented a better-preserved structure of the islets.
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Inhibition of advanced glycation endproduct formation by foodstuffs.
TL;DR: The development and investigation of AGE inhibitors, especially the natural anti-AGE agents without adverse effects, may provide a therapeutic approach for delaying and preventing premature aging and diabetic complications.
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1,2-dicarbonyl compounds in commonly consumed foods.
TL;DR: 1,2-dicarbonyl compounds, formed from carbohydrates during thermal processing in the course of caramelization and Maillard reactions, are intensively discussed as precursors for advanced glycation endproducts in foods and in vivo.
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Processing strawberries to different products alters contents of vitamin C, total phenolics, total anthocyanins, and antioxidant capacity.
TL;DR: Investigations on total phenolics in strawberry products proved fining to be a mild method to clarify berry juices and wines without removing high amounts of total phenolic.
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Determination of Advanced Glycation End Products in Serum by Fluorescence Spectroscopy and Competitive ELISA
Gerald Münch,Regina Keis,Andrea Weßels,Peter Riederer,Udo Bahner,August Heidland,Toshimitsu Niwa,Horst-Dieter Lemke,Reinhard Schinzel +8 more
TL;DR: An accurate and rapid assay for their determination would be useful for monitoring the removal of advanced glycation endproducts by novel dialysis membranes, as well as the effect of new drugs for the inhibition of their formation.