Journal ArticleDOI
Advanced glycation endproducts in food and their effects on health.
Malene W. Poulsen,Rikke Susanne Vingborg Hedegaard,Jeanette M. Andersen,Barbora de Courten,Barbora de Courten,Susanne Bügel,John Nielsen,Leif H. Skibsted,Lars O. Dragsted +8 more
Reads0
Chats0
TLDR
The current review points out several research needs in order to address important questions on AGEs in foods and health.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-10-01. It has received 540 citations till now. The article focuses on the topics: 3-Deoxyglucosone.read more
Citations
More filters
Journal ArticleDOI
Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
TL;DR: A review will highlight the involvement of AGEs in the development and progression of T2DM and their role in diabetic complications and the role of oxidative stress in hyperglycemia-induced tissue injury.
Journal ArticleDOI
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease ☆
TL;DR: Molecular mechanisms that link obesity, diabetes and AD, including oxidative stress, mitochondrial dysfunction, and inflammation that are observed in these disorders are discussed.
Journal ArticleDOI
Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms.
TL;DR: The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus, and understanding the pathogenic mechanisms of AGEs is paramount to develop strategies against diabetic and cardiovascular complications.
Journal ArticleDOI
A synopsis on aging-Theories, mechanisms and future prospects
João Pinto da Costa,Rui Vitorino,Gustavo M. Silva,Christine Vogel,Armando C. Duarte,Teresa Rocha-Santos +5 more
TL;DR: Some of the most relevant changes that take place during aging are explored and an integrative approach that couples aging research with systems biology, capable of providing novel insights into how and why the authors age, is necessary.
Journal ArticleDOI
Dietary Advanced Glycation End Products and Their Role in Health and Disease
Jaime Uribarri,María Dolores del Castillo,María Pía de la Maza,Rosana Filip,Alejandro Gugliucci,Claudia Luevano-Contreras,Maciste H. Macías-Cervantes,Deborah Helena Markowicz Bastos,Alejandra Medrano,Teresita Menini,Manuel Portero-Otin,Armando Rojas,Geni Rodrigues Sampaio,Kazimierz Wrobel,Katarzyna Wrobel,Ma. Eugenia Garay-Sevilla +15 more
TL;DR: This review illustrates currently known facts about dietary AGEs as well as pointing out areas that require further research.
References
More filters
Journal ArticleDOI
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy
Helen Vlassara,Weijing Cai,Jill P. Crandall,Teresia Goldberg,Robert Oberstein,Veronique Dardaine,Melpomeni Peppa,Elliot J. Rayfield +7 more
TL;DR: In diabetes, environmental (dietary) AGEs promote inflammatory mediators, leading to tissue injury, and Restriction of dietary A GEs suppresses these effects.
Journal ArticleDOI
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.
Mahtab U. Ahmed,Elisabeth Brinkmann Frye,Thorsten P. Degenhardt,Suzanne R. Thorpe,John W. Baynes +4 more
TL;DR: Levels of CML and CEL are proposed to provide an index of glyoxal and methylglyoxal concentrations in tissues, alterations in glutathione homoeostasis and dicarbonyl metabolism in disease, and sources of advanced glycation end-products in tissue proteins in aging and disease.
Journal ArticleDOI
Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry
Paul J. Thornalley,Sinan Battah,Naila Ahmed,Nikolaos Karachalias,Stamatina Agalou,Roya Babaei-Jadidi,Anne Dawnay +6 more
TL;DR: Comprehensive screening of glycation adducts revealed the relative and quantitative importance of alpha-oxoaldehyde-derived advanced glycation endproducts in physiological modification of proteins-particularly hydroimidazolones, the efficient renal clearance of freeAdducts, and the marked increases in glycationadducts in diabetes and uraemia.
Journal ArticleDOI
Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish.
TL;DR: Avoidance of exposure to HCAs or reduction of HCAs’biological effects as far as possible are to be highly recommended, and usage of microwave ovens for cooking and supplementation of the diet, for example with soy‐isoflavones, which have been found to suppress the occurrence of HCA‐induced breast cancers, should be encouraged.
Journal ArticleDOI
Lipid advanced glycosylation : pathway for lipid oxidation in vivo
TL;DR: Data support the concept that AGE oxidation plays an important and perhaps primary role in initiating lipid oxidation in vivo, and increased levels of both apoprotein- and lipid-linked AGEs when compared to specimens obtained from normal, nondiabetic controls.