Journal ArticleDOI
Advanced glycation endproducts in food and their effects on health.
Malene W. Poulsen,Rikke Susanne Vingborg Hedegaard,Jeanette M. Andersen,Barbora de Courten,Barbora de Courten,Susanne Bügel,John Nielsen,Leif H. Skibsted,Lars O. Dragsted +8 more
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The current review points out several research needs in order to address important questions on AGEs in foods and health.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-10-01. It has received 540 citations till now. The article focuses on the topics: 3-Deoxyglucosone.read more
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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
TL;DR: A review will highlight the involvement of AGEs in the development and progression of T2DM and their role in diabetic complications and the role of oxidative stress in hyperglycemia-induced tissue injury.
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Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease ☆
TL;DR: Molecular mechanisms that link obesity, diabetes and AD, including oxidative stress, mitochondrial dysfunction, and inflammation that are observed in these disorders are discussed.
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Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms.
TL;DR: The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus, and understanding the pathogenic mechanisms of AGEs is paramount to develop strategies against diabetic and cardiovascular complications.
Journal ArticleDOI
A synopsis on aging-Theories, mechanisms and future prospects
João Pinto da Costa,Rui Vitorino,Gustavo M. Silva,Christine Vogel,Armando C. Duarte,Teresa Rocha-Santos +5 more
TL;DR: Some of the most relevant changes that take place during aging are explored and an integrative approach that couples aging research with systems biology, capable of providing novel insights into how and why the authors age, is necessary.
Journal ArticleDOI
Dietary Advanced Glycation End Products and Their Role in Health and Disease
Jaime Uribarri,María Dolores del Castillo,María Pía de la Maza,Rosana Filip,Alejandro Gugliucci,Claudia Luevano-Contreras,Maciste H. Macías-Cervantes,Deborah Helena Markowicz Bastos,Alejandra Medrano,Teresita Menini,Manuel Portero-Otin,Armando Rojas,Geni Rodrigues Sampaio,Kazimierz Wrobel,Katarzyna Wrobel,Ma. Eugenia Garay-Sevilla +15 more
TL;DR: This review illustrates currently known facts about dietary AGEs as well as pointing out areas that require further research.
References
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Journal ArticleDOI
Glycolaldehyde-modified β-lactoglobulin AGEs are unable to stimulate inflammatory signaling pathways in RAGE-expressing human cell lines.
Timo Buetler,Hélia Latado,Estelle Leclerc,Bernd Weigle,Alexandra Baumeyer,Claus W. Heizmann,Gabriele Scholz +6 more
TL;DR: It is demonstrated that glycolaldehyde-modified AGEs are unable to induce inflammatory signaling in receptor for AGE-expressing cells and affinity column purification was insufficient to remove this contamination.
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A straightforward synthesis of pentosidine framework
TL;DR: In this paper, the synthesis of the pentosidine framework (X) consists of a five-step sequence which provides the target compound in a satisfactory overall yiel (75%).
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Marginal thiamine deficiency increases oxidative markers in the plasma and selected tissues in F344 rats
TL;DR: The brain, liver, and colon showed similar trends, with evident tissue specificity, and diets marginally deficient inThiamine increase the endogenous formation of carbonyl products at thiamine levels only slightly below the requirement levels, 4 mg/kg diet (0.25 mg/kJ diet).