ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome.
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TLDR
Investigating the stem-cell-related function and clinical significance of the ALDH1A1 in human PCa found it to be a prostate CSC-related marker and measuring its expression might provide a potential approach to study tumorigenesis of PCa and predict outcome of the disease.About:
This article is published in Laboratory Investigation.The article was published on 2010-02-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Cancer stem cell & Prostate cancer.read more
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Journal ArticleDOI
Understanding cancer stem cell heterogeneity and plasticity.
TL;DR: By understanding the interrelationship between CSCs and their differentiated progeny, the authors can hope to develop better therapeutic regimens that can prevent the emergence of tumor cell variants that are able to found a new tumor and distant metastases.
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The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells
TL;DR: A comprehensive review discusses the role that ALDH plays in normal stem cells and CSCs, with focus on ALDH1 and ALDH3A1.
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Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform
TL;DR: The suggested roles of ALDH in CSC biology and the immunohistological studies testing the potential application of AL DH isoforms as novel cancer prognostic indicators are reviewed.
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Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis
Paola Marcato,Cheryl A. Dean,Da Pan,Rakhna Araslanova,Megan E. Gillis,Madalsa Joshi,Lucy Helyer,Lu-Zhe Pan,Andrew M. Leidal,Shashi Gujar,Carman A. Giacomantonio,Patrick W. K. Lee +11 more
TL;DR: The results identified ALDH1A3 as a novel CSC marker with potential clinical prognostic applicability, and demonstrate a clear correlation between CSC prevalence and the development of metastatic breast cancer, as well as shRNA knockdown experiments of the various ALDH isoforms.
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Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers
Shan Deng,Shan Deng,Xiaojun Yang,Xiaojun Yang,Heini Lassus,Shun-Zhi Liang,Sippy Kaur,Qunrui Ye,Chunsheng Li,Li-Ping Wang,Katherine F. Roby,Sandra Orsulic,Denise C. Connolly,Youcheng Zhang,Kathleen T. Montone,Ralf Bützow,George Coukos,Lin Zhang +17 more
TL;DR: It is found that high AL DH1 expression is significantly associated with poor clinical outcomes in serous ovarian cancer patients and high ALDHbr tumor cells exhibit cancer stem cell properties and are resistant to chemotherapy.
References
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Stem cells, cancer, and cancer stem cells
TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Christophe Ginestier,Min Hee Hur,Emmanuelle Charafe-Jauffret,Florence Monville,Julie Dutcher,Marty Brown,Jocelyne Jacquemier,Patrice Viens,Celina G. Kleer,Suling Liu,Anne F. Schott,Daniel F. Hayes,Daniel Birnbaum,Max S. Wicha,Gabriela Dontu +14 more
TL;DR: It is shown that normal and cancer human mammary epithelial cells with increased aldehyde dehydrogenase activity (ALDH) have stem/progenitor properties and these cells contain the subpopulation of normal breast epithelium with the broadest lineage differentiation potential and greatest growth capacity in a xenotransplant model.
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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
Michael F. Clarke,John E. Dick,Peter B. Dirks,Connie J. Eaves,Catriona Jamieson,D. Leanne Jones,Jane E. Visvader,Irving L. Weissman,Geoffrey M. Wahl +8 more
TL;DR: A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression, and participants were charged with evaluating data suggesting that cancers develop from a small subset of cells with self-renewal properties analogous to organ regeneration.
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Cancer Stem Cells
TL;DR: This review describes cancer stem cells, a topic of considerable biologic and clinical interest in oncology.
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CD133, a novel marker for human prostatic epithelial stem cells
Gavin D. Richardson,Craig N. Robson,Shona H. Lang,David E. Neal,Norman J. Maitland,Anne T. Collins +5 more
TL;DR: In this article, a small population of human prostate basal cells express the cell surface marker CD133 and are restricted to the alpha(2)beta(1)(hi) population, previously identified as a marker of stem cells in prostate epithelia.