An update on larynx cancer.
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TLDR
The care for patients with laryngeal cancer continues to evolve and truly requires a multidisciplinary team-based approach as discussed by the authors, which is the most common cause of lung cancer deaths.Abstract:
Answer questions and earn CME/CNE Laryngeal cancer remains one of the most common tumors of the respiratory tract. Fortunately, significant advancements have been made over the past decade in the treatment of laryngeal cancer. Although surgery has been the historical mainstay for localized disease and still is an integral part of treatment, nonsurgical options like radiation and systemic therapy have emerged as viable options. In addition, in the metastatic setting, novel agents are showing promise for this patient population. The care for patients with laryngeal cancer continues to evolve and truly requires a multidisciplinary team-based approach. Unique morbidities, such as loss of natural voice, respiration, and airway protection during swallowing, are observed with this disease and require special consideration. CA Cancer J Clin 2017;67:31-50. © 2016 American Cancer Society.read more
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Updates on larynx cancer epidemiology.
TL;DR: Laryngeal cancer still poses a high clinical and societal burden, with an escalating temporal trend not expected to reverse soon, and the ratio between deaths and incidence is the highest in Africa.
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Rapid histology of laryngeal squamous cell carcinoma with deep-learning based stimulated Raman scattering microscopy.
Lili Zhang,Yongzheng Wu,Bin Zheng,Lizhong Su,Yuan Chen,Shuang Ma,Qinqin Hu,Xiang Zou,Lie Yao,Yinlong Yang,Liang Chen,Ying Mao,Yan Chen,Minbiao Ji +13 more
TL;DR: The results indicated that SRS histology integrated with deep learning algorithm provides potential for delivering rapid intraoperative diagnosis that could aid the surgical management of laryngeal cancer.
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circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway
Wei Gao,Guo Huina,Min Niu,Zheng Xiwang,Yuliang Zhang,Xue Xuting,Yunfeng Bo,Guan Xiaoya,Li Zhongxun,Yujia Guo,Long He,Yu Zhang,Li Li,Jimin Cao,Yongyan Wu +14 more
TL;DR: This study reveals that the novel autophagy-suppressive circPARD3 promotes LSCC progression and chemoresistance through the PRKCI-Akt-mTOR pathway, providing new insights into circRNA-mediated autophagic regulation and potential biomarker and target for LSCC treatment.
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Biological Function of Long Non-coding RNA (LncRNA) Xist.
Wenlun Wang,Lu Min,Xin-yuan Qiu,Xiaomin Wu,Chuanyang Liu,Jiaxin Ma,Dong-Yi Zhang,Lingyun Zhu +7 more
TL;DR: Cao et al. as mentioned in this paper summarized recent progress in understanding the cellular functions of long non-coding RNA X-inactive specific transcript (lncRNA Xist) in mammalian cells and discussed current knowledge regarding the ceRNA network of lnc RNA Xist in various diseases.
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Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis
Yongyan Wu,Yuliang Zhang,Zheng Xiwang,Dai Fengsheng,Yan Lu,Dai Li,Min Niu,Guo Huina,Li Wenqi,Xue Xuting,Yunfeng Bo,Yujia Guo,Jiangbo Qin,Yixiao Qin,Liu Hongliang,Yu Zhang,Tao Yang,Li Li,Linshi Zhang,Rui Hou,Shuxin Wen,Changming An,Huizheng Li,Xu Wei,Wei Gao +24 more
TL;DR: Mechanistic studies revealed that circCORO1C competitively bound to let-7c-5p and prevented it from decreasing the level of PBX3, which facilitated the malignant progression of LSCC and may serve as a novel target for LSCC therapy.
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