Andrographolide engineered gold nanoparticle to overcome drug resistant visceral leishmaniasis.
Suvadra Das,Asim Halder,Saptarshi Mandal,Mohammad A. Jafar Mazumder,Tanmoy Bera,Arup Mukherjee,Partha Roy +6 more
TLDR
This study aims to arrive at terpenoid andrographolide engineered gold nanoparticle (AGAunps) facile synthesis and its efficacy evaluations against wild and drug resistant VL strains for the first time.Abstract:
Visceral leishmaniasis (VL) is World Health Organization designated most serious leishmaniasis with an annual mortality rate of 50,000. Even after country specific eradication programs, the disease...read more
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Synthesis, characterization, and mechanistic studies of a gold nanoparticle-amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity.
Prakash Kumar,Pushkar Shivam,Saptarshi Mandal,Pragya Prasanna,Saurabh Kumar,Surendra Prasad,Ashish Kumar,Prolay Das,Vahab Ali,Shubhankar K. Singh,Debabrata Mandal +10 more
TL;DR: GNP-based delivery of AmB can be a better, cheaper, and safer alternative than available AmB formulations, and improved antileishmanial efficacy and reduced cytotoxicity.
Journal ArticleDOI
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health.
Jing Zhang,Kaili Hu,Liuqing Di,Penglong Wang,Zhidong Liu,Jinming Zhang,Pengfei Yue,Wantong Song,Jingwei Zhang,Tongkai Chen,Zuhua Wang,Yongtai Zhang,Xiaoying Wang,Changyou Zhan,Yung-Chi Cheng,Xiang Li,Quan Li,Jing-Yu Fan,Youqing Shen,Jing-Yan Han,Hongzhi Qiao +20 more
TL;DR: In this article, the authors discuss the overlapping connectivity and relevance of the two fields, including nanoaggregates generated in herbal medicine decoctions, the application of nanotechnology in the delivery and treatment of natural active ingredients, and the influence of physiological regulatory capability of traditional herbal medicine on the in vivo fate of nanoparticles.
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Andrographolide Loaded in Micro- and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the “King of Bitters”
Marta Casamonti,Laura Risaliti,Giulia Vanti,Vieri Piazzini,Maria Camilla Bergonzi,Anna Rita Bilia +5 more
TL;DR: This review reports on published studies related to microparticles (MPs) and nanoparticles (NPs) loaded with Andrographolide and improved bioavailability, target-tissue distribution, and efficacy of AG loaded in the described drug delivery systems have been reported.
Journal ArticleDOI
Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action.
Zoya Malik,Rabea Parveen,Bushra Parveen,Sultan Zahiruddin,Mohammad Aasif Khan,Asifa Khan,Sheersh Massey,Sayeed Ahmad,Syed Akhtar Husain +8 more
TL;DR: In this article, the main emphasis was given on the anticancer activity of AG, its proposed mechanisms of action, novel approaches used to improve its biopharmaceutical properties, and its development as an adjuvant therapy for cancer treatment in future.
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Current status of nanoscale drug delivery and the future of nano-vaccine development for leishmaniasis - A review.
Pragya Prasanna,Prakash Kumar,Saurabh Kumar,Vinod Kumar Rajana,Vishnu Kant,Surendra Prasad,Utpal Mohan,Velayutham Ravichandiran,Debabrata Mandal +8 more
TL;DR: In this article, the role of physicochemical properties of a nanoscale delivery system is discussed and different ways of nano-formulation delivery ranging from liposome, niosomes, polymeric, metallic, solid-lipid NPs were updated along with the possible mechanisms of action against the parasite.
References
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Drug Resistance in Leishmaniasis
TL;DR: It is essential that there be a strategy to prevent the emergence of resistance to new drugs; combination therapy, monitoring of therapy, and improved diagnostics could play an essential role in this strategy.
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Leishmaniasis– current chemotherapy and recent advances in the search for novel drugs
Simon L. Croft,Graham H. Coombs +1 more
TL;DR: The immunomodulator imiquimod has proved to be an adjunct for CL therapy and the search for new drugs continues, with bisphosphonates, for example, risedronate and pamidronate, and plant derivatives being reported to have activity against experimental animal infections.
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Biological synthesis of gold nanoparticles using Magnolia kobus and Diopyros kaki leaf extracts
TL;DR: In this paper, two plants, Magnolia kobus and Diopyros kaki, were used for ecofriendly extracellular synthesis of metallic gold nanoparticles, which were formed by treating an aqueous HAuCl 4 solution using the plant leaf extracts as reducing agents.
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Biosynthesis of nanoparticles by microorganisms and their applications
TL;DR: In this paper, the development of eco-friendly technologies in material synthesis is of considerable importance to expand their biological applications, and a variety of inorganic nanoparticles with well-defined chemical composition, size and morphology have been synthesized by using different microorganisms, and their applications in many cutting-edge technological areas have been explored.