Andrographolide engineered gold nanoparticle to overcome drug resistant visceral leishmaniasis.
Suvadra Das,Asim Halder,Saptarshi Mandal,Mohammad A. Jafar Mazumder,Tanmoy Bera,Arup Mukherjee,Partha Roy +6 more
TLDR
This study aims to arrive at terpenoid andrographolide engineered gold nanoparticle (AGAunps) facile synthesis and its efficacy evaluations against wild and drug resistant VL strains for the first time.Abstract:
Visceral leishmaniasis (VL) is World Health Organization designated most serious leishmaniasis with an annual mortality rate of 50,000. Even after country specific eradication programs, the disease...read more
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Synthesis, characterization, and mechanistic studies of a gold nanoparticle-amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity.
Prakash Kumar,Pushkar Shivam,Saptarshi Mandal,Pragya Prasanna,Saurabh Kumar,Surendra Prasad,Ashish Kumar,Prolay Das,Vahab Ali,Shubhankar K. Singh,Debabrata Mandal +10 more
TL;DR: GNP-based delivery of AmB can be a better, cheaper, and safer alternative than available AmB formulations, and improved antileishmanial efficacy and reduced cytotoxicity.
Journal ArticleDOI
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health.
Jing Zhang,Kaili Hu,Liuqing Di,Penglong Wang,Zhidong Liu,Jinming Zhang,Pengfei Yue,Wantong Song,Jingwei Zhang,Tongkai Chen,Zuhua Wang,Yongtai Zhang,Xiaoying Wang,Changyou Zhan,Yung-Chi Cheng,Xiang Li,Quan Li,Jing-Yu Fan,Youqing Shen,Jing-Yan Han,Hongzhi Qiao +20 more
TL;DR: In this article, the authors discuss the overlapping connectivity and relevance of the two fields, including nanoaggregates generated in herbal medicine decoctions, the application of nanotechnology in the delivery and treatment of natural active ingredients, and the influence of physiological regulatory capability of traditional herbal medicine on the in vivo fate of nanoparticles.
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Andrographolide Loaded in Micro- and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the “King of Bitters”
Marta Casamonti,Laura Risaliti,Giulia Vanti,Vieri Piazzini,Maria Camilla Bergonzi,Anna Rita Bilia +5 more
TL;DR: This review reports on published studies related to microparticles (MPs) and nanoparticles (NPs) loaded with Andrographolide and improved bioavailability, target-tissue distribution, and efficacy of AG loaded in the described drug delivery systems have been reported.
Journal ArticleDOI
Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action.
Zoya Malik,Rabea Parveen,Bushra Parveen,Sultan Zahiruddin,Mohammad Aasif Khan,Asifa Khan,Sheersh Massey,Sayeed Ahmad,Syed Akhtar Husain +8 more
TL;DR: In this article, the main emphasis was given on the anticancer activity of AG, its proposed mechanisms of action, novel approaches used to improve its biopharmaceutical properties, and its development as an adjuvant therapy for cancer treatment in future.
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Current status of nanoscale drug delivery and the future of nano-vaccine development for leishmaniasis - A review.
Pragya Prasanna,Prakash Kumar,Saurabh Kumar,Vinod Kumar Rajana,Vishnu Kant,Surendra Prasad,Utpal Mohan,Velayutham Ravichandiran,Debabrata Mandal +8 more
TL;DR: In this article, the role of physicochemical properties of a nanoscale delivery system is discussed and different ways of nano-formulation delivery ranging from liposome, niosomes, polymeric, metallic, solid-lipid NPs were updated along with the possible mechanisms of action against the parasite.
References
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Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.
TL;DR: A review of gold nanoparticles can be found in this article, where the most stable metal nanoparticles, called gold colloids (AuNPs), have been used for catalysis and biology applications.
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
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Green synthesis of metal nanoparticles using plants
TL;DR: Most of the plants used in metal nanoparticle synthesis are shown in this article, and the advantages of using plant and plant-derived materials for biosynthesis of metal nanoparticles have interested researchers to investigate mechanisms of metal ions uptake and bioreduction by plants, and to understand the possible mechanism of nanoparticle formation in plants.