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Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
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Theoretical study on Curcumin: A comparison of calculated spectroscopic properties with NMR, UV–vis and IR experimental data
TL;DR: In this article, a high-level computational analysis of Curcumin, employing DFT approach with two different sets of basis functions, is carried out with the aim of analyzing the conformational equilibria, to find the most stable equilibrium structure and to define the nature of the molecular orbitals.
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Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein
Hyun-Jong Cho,In-Soo Yoon +1 more
TL;DR: Ten popular medicinal and/or dietary herbs are reviewed as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions to provide robust fundamentals for optimizing CYP and/ or P- gp substrate drug-based therapy.
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Preparation and Characterization of Starch Nanoparticles for Controlled Release of Curcumin
TL;DR: Curcumin was loaded onto starch nanoparticles by using in situ nanoprecipitation method and water-in-oil micro-emulsion system as mentioned in this paper, which exhibited enhanced solubility in aqueous solution as compared to free curcumin.
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Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-κB transcription factor.
TL;DR: Whether curcumin can reverse chemoresistance by downregulating NF-κB in human gastric cancer cells is investigated and it is found thatCurcumin potentiates the antitumor effects of chemotherapeutics in Gastric cancer by suppressing NF-σκB and NF-γB-regulated anti-apoptotic genes.
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Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal:
TL;DR: Curcumin may have some protective role against the DNA damage caused by arsenic and this field trial evaluated the role of curcumin against the genotoxic effects of arsenic.
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Eitan Shaulian,Michael Karin +1 more
TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
Journal Article
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
Ann-Lii Cheng,Hsu Ch,Lin Jk,Hsu Mm,Yunn-Fang Ho,Shen Ts,Ko Jy,Lin Jt,Bor-Ru Lin,Ming-Shiang W,Yu Hs,Shiou-Hwa Jee,Chen Gs,Chen Tm,Chi-An Chen,Lai Mk,Yeong-Shiau Pu,Min-Hsiung Pan,Wang Yj,Tsai Cc,Hsieh Cy +20 more
TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
TL;DR: A model has been proposed for the cytokine‐induced E‐selectin enhancer that is similar to the stereospecific complex proposed forThe inter‐ feron‐β gene promoter, in which multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery.
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.