Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
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Stereoselective construction of carbocycles and heterocycles via cascade reactions involving curcumins and nitroalkenes
TL;DR: In this paper, the reaction of curcumins with nitroalkenes has been investigated for the first time, and the results showed that curcumin reacts with α-bromonitroalkene to afford dihydrofurans through an intermolecular Michael addition-intramolecular nucleophilic substitution (O-alkylation), which is analogous to an ‘interrupted’ Feist-Benary reaction.
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Therapeutic potentials of curcumin in the treatment of glioblstoma.
Zahra Shabaninejad,Mohammad Hossein Pourhanifeh,Ahmad Movahedpour,Reza Mottaghi,Ali Nickdasti,Erfan Mortezapour,Alimohammad Shafiee,Sarah Hajighadimi,Sanaz Moradizarmehri,Mohammad Sadeghian,Seyed Mojtaba Mousavi,Hamed Mirzaei +11 more
TL;DR: It is showed that curcumin exerts its therapeutic effects on GBM cells via affecting on apoptosis, oxidant system, and inflammatory pathways, and would possess a synergistic impact with chemotherapeutic agents.
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Curcumin Differentially Regulates Endoplasmic Reticulum Stress through Transcriptional Corepressor SMILE (Small Heterodimer Partner-interacting Leucine Zipper Protein)-mediated Inhibition of CREBH (cAMP Responsive Element-binding Protein H)
Jagannath Misra,Dipanjan Chanda,Don Kyu Kim,Tiangang Li,Seung Hoi Koo,Sung Hoon Back,John Y.L. Chiang,Hueng Sik Choi +7 more
TL;DR: A novel phenomenon is suggested that the curcumin/LKB1/AMPK/SMILE/PGC1α pathway differentially regulates ER stress-mediated gene transcription.
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Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents
Nawras Samaan,Qiu Zhong,Jayjoel Fernandez,Guanglin Chen,Ali M. Hussain,Shilong Zheng,Guangdi Wang,Qiao-Hong Chen +7 more
TL;DR: Nitrogen-containing heteroaromatic rings are promising bioisosteres of the substituted phenyl ring in curcumin according to cytotoxicity values and selective enhancement of cell death in prostate cancer cell lines and other aggressive cancer cell Lines suggests that nitrogen-containing heterogeneity is promising.
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Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells.
Gangotri Siddappa,Safeena Kulsum,Ravindra Dr,Vinay Kumar,Nalini Raju,Nisheena Raghavan,Holalugunda Vittalamurthy Sudheendra,Anupam Sharma,Sumsum P. Sunny,Tina Jacob,Binu T. Kuruvilla,Merina Benny,Benny Antony,Mukund Seshadri,Padma Lakshminarayan,Wesley L. Hicks,Amritha Suresh,Moni Abraham Kuriakose +17 more
TL;DR: The observations suggest that the combination of curcumin and metformin may improve chemopreventive efficacy against oral squamous cell carcinoma through a CSC‐associated mechanism.
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Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.