Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
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A Randomized Double-Blind Placebo-Controlled Phase IIB Trial of Curcumin in Oral Leukoplakia.
Moni Abraham Kuriakose,Moni Abraham Kuriakose,Kunnambath Ramdas,Bindu Dey,Subramanya Iyer,Gunaseelan Rajan,Kalavathy K. Elango,Amritha Suresh,Divya Ravindran,Rajneesh R. Kumar,Prathiba R,Surya Ramachandran,Nisha Asok Kumar,Gigi Thomas,Thara Somanathan,Hiran K Ravindran,Kannan Ranganathan,Sudhakar Babu Katakam,Shivashankar Parashuram,Vijayvel Jayaprakash,M. Radhakrishna Pillai +20 more
TL;DR: Treatment of oral leukoplakia with curcumin was well tolerated and demonstrated significant and durable clinical response for 6 months, and the treatment did not raise any safety concerns.
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Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer
Haitao Yin,Rui Guo,Yong Xu,Yulong Zheng,Zhibo Hou,Xinzheng Dai,Zhengdong Zhang,Donghui Zheng,Huae Xu +8 more
TL;DR: In vitro and in vivo evaluations demonstrated the satisfying synergistic antitumor efficacy of Cum and Doc against lung cancer and the introduction of Cum in traditional chemotherapy is a most promising way to counter the spread of non-small cell lung cancer.
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Interaction of curcumin with PEO–PPO–PEO block copolymers: a molecular dynamics study
Susruta Samanta,Danilo Roccatano +1 more
TL;DR: The study shows that the more hydrophobic 1,2-dimethoxypropane molecules and PPO block preferentially coat the Curcumin molecule, and simulation shows formation of a drug-polymer aggregate within 50 ns, resulting in better solvation and stability of the drug in water.
Journal ArticleDOI
Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics
Lihua Wang,Lihua Wang,Xiwen Chen,Zhuanyun Du,Gefei Li,Mayun Chen,Xi Chen,Guang Liang,Tongke Chen +8 more
TL;DR: A novel mechanism by which curcumin inhibited gastric tumor growth through excessive ROS generation, resulting in depletion of POLG and mtDNA, and the subsequent disruption of cellular bioenergetics is suggested.
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Therapeutic implications of curcumin in the prevention of diabetic retinopathy via modulation of anti-oxidant activity and genetic pathways.
TL;DR: Curcumin, constituents of dietary spice turmeric, has been observed to have therapeutic potential in the inhibition or slow down progression of DR through antioxidant, anti-inflammatory, inhibition of Vascular Endothelial Growth and nuclear transcription factors.
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TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
TL;DR: A model has been proposed for the cytokine‐induced E‐selectin enhancer that is similar to the stereospecific complex proposed forThe inter‐ feron‐β gene promoter, in which multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery.
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.