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Anticancer potential of curcumin: preclinical and clinical studies.

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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.
Abstract
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indian

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Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer.

TL;DR: The current knowledge of apoptosis regulation by curcumin in CRC is described with regard to molecular targets and associated signaling pathways.
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Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells

TL;DR: It is reported that curcumin's apoptosis-inducing effects in colon cancer cell lines are accompanied by robust ceramide generation, indicating, for the first time, that endogenous ceramidegeneration by this agent contributes towards its biological activity.
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Efficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic Patients.

TL;DR: Turmeric supplementation as an adjuvant to T2DM on metformin treatment had a beneficial effect on blood glucose, oxidative stress and inflammation.
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The unexpected role of lymphotoxin |[beta]| receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development

TL;DR: The pleiotropic functions attributed to LT, the effects of its deregulation and extensively discuss the recent literature on LT's link to carcinogenesis are reviewed.
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Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia.

TL;DR: The efficient targeting and therapeutic efficacy of a combination of drugs and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands resulted in the superior uptake of nanoparticles by cancer cells.
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Journal Article

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.

TL;DR: A model has been proposed for the cytokine‐induced E‐selectin enhancer that is similar to the stereospecific complex proposed forThe inter‐ feron‐β gene promoter, in which multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery.
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers

TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
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