Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
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Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.
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Delivery of curcumin and medicinal effects of the copper(II)-curcumin complexes.
TL;DR: Curcumin has dual roles as an anti-oxidant and a prooxidants in the presence of copper and these fascinating phenomena contribute greatly to its multiple medicinal effects.
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The effects of Curcuma longa and curcumin on reproductive systems
TL;DR: A detailed literature survey concentrated on the protective effects of C. longa and curcumin on the reproductive organs activity found that they might decrease the risk of cancer and other malignant diseases in the reproductive system and showed pro-apoptotic effects in the malignant cells.
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Modulation of stability and functionality of a phyto-antioxidant by weakly interacting metal ions: curcumin in aqueous solution
Damayanti Bagchi,Siddhi Chaudhuri,Samim Sardar,Susobhan Choudhury,Nabarun Polley,Peter Lemmens,Samir Kumar Pal +6 more
TL;DR: In this paper, the stability and functionality of metallo-curcumin complexes with transition metal ions were investigated and a facile method that enhances the solubility and stability of curcumin in aqueous media by metalation with Zn (II) and a successional replacement of Zn(II) in the complex by Cu(II), through a simple route to enhance the activity before its use.
Book ChapterDOI
Plant Polyphenols as Chemopreventive Agents
TL;DR: Current knowledge on the use of plant-derived phenolic compounds in cancer chemopreventive agents and sources of polyphenols in human diet are summarized.
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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
TL;DR: A model has been proposed for the cytokine‐induced E‐selectin enhancer that is similar to the stereospecific complex proposed forThe inter‐ feron‐β gene promoter, in which multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery.
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.