Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
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Molecular basis of the Cotton effects induced by the binding of curcumin to human serum albumin
TL;DR: It is established that the phenolic OH group of curcumin is the most acidic and that its dissociation is responsible for both the large red-shift of the main absorption band and the binding ofCurcumin to HSA in a right-handed chiral conformation.
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Neuroprotective efficacy of curcumin in arsenic induced cholinergic dysfunctions in rats
Rajesh Singh Yadav,Lalit P. Chandravanshi,Rajendra K. Shukla,Madhu Lata Sankhwar,Reyaz W. Ansari,Pradeep K. Shukla,Aditya B. Pant,Vinay K. Khanna +7 more
TL;DR: Curcumin significantly modulates arsenic induced cholinergic dysfunctions in brain and also exhibits neuroprotective efficacy of curcumin, suggesting that chronic exposure to arsenic is associated with cognitive deficits in humans.
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Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting
Mukta Agrawal,Swarnlata Saraf,Shailendra Saraf,Sunil Kumar Dubey,Anu Puri,Ravish J. Patel,Ajazuddin,V. Ravichandiran,Upadhyayula Suryanarayana Murty,Amit Alexander +9 more
TL;DR: The role and application of NLC is described in detail, along with its different fabrication techniques and associated limitations, for brain targeting of bioactives with particular reference to its surface modifications, formulations aspects, pharmacokinetic behavior and efficacy towards the treatment of various neurological disorders.
Journal ArticleDOI
Bioavailability enhancement of curcumin by complexation with phosphatidyl choline.
Nishant Gupta,Vinod Kumar Dixit +1 more
TL;DR: The results of ex vivo study show that CU-PC complex has significantly increased absorption compared with curcumin, when given in equimolar doses, and enhanced bioavailability and improved pharmacokinetics.
Journal ArticleDOI
Curcumin induces apoptosis and inhibits prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis
Cheol Park,Dong-Oh Moon,Il-Whan Choi,Byung Tae Choi,Taek-Jeong Nam,Chung-Ho Rhu,Taeg Kyu Kwon,Wonho Lee,Gi-Young Kim,Yung Hyun Choi +9 more
TL;DR: Results show that curcumin might help identify a new therapeutic pathway against hyperplasia of the synovial fibroblasts in RA.
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Journal Article
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
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TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
TL;DR: A model has been proposed for the cytokine‐induced E‐selectin enhancer that is similar to the stereospecific complex proposed forThe inter‐ feron‐β gene promoter, in which multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery.
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.