Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
Reads0
Chats0
TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
Citations
More filters
Journal ArticleDOI
Bioavailability of curcumin: problems and promises.
TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Journal ArticleDOI
Gut Microbiota in Health and Disease
TL;DR: The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.
Journal ArticleDOI
Curcumin as “Curecumin”: From kitchen to clinic
TL;DR: Curcumin, a spice once relegated to the kitchen shelf, has moved into the clinic and may prove to be "Curecumin", a therapeutic agent in wound healing, diabetes, Alzheimer disease, Parkinson disease, cardiovascular disease, pulmonary disease, and arthritis.
Journal ArticleDOI
Curcumin: From ancient medicine to current clinical trials
TL;DR: Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimer’s disease.
Journal ArticleDOI
Curcumin: The story so far
TL;DR: Sufficient data currently exist to advocate phase II clinical evaluation of oral curcumin in patients with invasive malignancy or pre-invasive lesions of the gastrointestinal tract, particularly the colon and rectum.
References
More filters
Journal ArticleDOI
Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa
TL;DR: These compounds showed activity against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines, and good inhibition of the COX-II enzyme was observed.
Journal Article
Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers.
TL;DR: The study of curcumin as a chemopreventive substance against arterial diseases is suggested after a significant decrease in the level of serum lipid peroxides, increase in HDL Cholesterol, and decrease in total serum cholesterol were noted.
Journal ArticleDOI
Curcuminoids Inhibit the Angiogenic Response Stimulated by Fibroblast Growth Factor-2, Including Expression of Matrix Metalloproteinase Gelatinase B
Royce Mohan,Jeremy M Sivak,Paul Ashton,Laoti A. Russo,Bao Q. Pham,Niro Kasahara,Michael B. Raizman,M. Elizabeth Fini +7 more
TL;DR: Evidence is provided that curcuminoids target the FGF-2 angiogenic signaling pathway and inhibit expression of gelatinase B in theAngiogenic process, and induction of gelatinases B transcriptional promoter activity in response to F GF-2 is dependent on AP-1 but not NF-κB response elements and that promoter activity is also inhibited byCurcuminoid.
Journal ArticleDOI
Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes
TL;DR: The findings highlight the fact that curcumin inhibits EAE by blocking IL-12 signaling in T cells and suggest its use in the treatment of MS and other Th1 cell-mediated inflammatory diseases.
Journal ArticleDOI
Inhibitory effects of curcumin on protein kinase c activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in nih 3t3 cells
TL;DR: Findings suggest that the suppression of PKC activity may contribute to the molecular mechanism of inhibition of TPA-induced tumor promotion by curcumin.