Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
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Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells.
Lu Wang,Xiaoping Xu,Yi(张益) Zhang,Yuanqing Zhang,Ying(诸颖) Zhu,Jiye Shi,Jiye Shi,Yanhong(孙艳红) Sun,Qing(黄庆) Huang +8 more
TL;DR: The results indicated that the G5-Ac drug delivery system could improve the solubility and anti-cancer effect of curcumin and showed higher anti-proliferative activity against A549 cell lines and had the better effect on the generation of intracellular reactive oxygen species and cell apoptosis.
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Metabolism of curcumin and induction of mitotic catastrophe in human cancer cells
TL;DR: The results imply that the causative agent of mitotic catastrophe is the parent CUR molecule, whereas reductive metabolism and chemical degradation render CUR inactive.
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Protamine‐Capped Mesoporous Silica Nanoparticles for Biologically Triggered Drug Release
Krishna Radhakrishnan,Satyajit Gupta,Divya Prakash Gnanadhas,Praveen C. Ramamurthy,Dipshika Chakravortty,Ashok M. Raichur,Ashok M. Raichur +6 more
TL;DR: The fabrication of a mesoporous silica nanoparticle (MSN)−protamine hybrid system (MSN−PRM) is reported that selectively releases drugs in the presence of specific enzyme triggers present in the proximity of cancer cells, and is a promising platform for cancer specific drug delivery.
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Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro
Christian Ciardi,Marcel Jenny,Alexander Tschoner,Florian Ueberall,Josef R. Patsch,Michael T. Pedrini,Christoph Ebenbichler,Dietmar Fuchs +7 more
TL;DR: Investigation of the influence of food additives on the release of leptin, IL-6 and nitrite in the presence of LPS in murine adipocytes found that decreased leptin release during the consumption of nutrition-derived food additives could decrease the amount of circulating leptin and may therefore contribute to an obesogenic environment.
Journal ArticleDOI
Novel Drug Delivery Systems to Improve Bioavailability of Curcumin
TL;DR: The various novel drug delivery systems of curcumin such as various nanoparticles, micellar formulations, liposomes and cyclodextrin inclusion complexes that have been reported in order to improve the solubility, bioavailability and efficacy ofCurcumin are discussed.
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Journal Article
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TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
TL;DR: A model has been proposed for the cytokine‐induced E‐selectin enhancer that is similar to the stereospecific complex proposed forThe inter‐ feron‐β gene promoter, in which multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery.
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.