Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
Reads0
Chats0
TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
Citations
More filters
Journal ArticleDOI
Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability.
TL;DR: Curcumin micelles proved to be more efficient in preventing mitochondrial swelling in isolated mouse brain mitochondria and protecting PC12 cells from nitrosative stress than native curcumin, indicating less mitochondrial permeability transition pore (mPTP) opening and prevention of injury.
Journal ArticleDOI
Targeting Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase 2 by Curcumin Induces ER Stress-Associated Apoptosis for Treating Human Liposarcoma
Lu Wang,Lingxian Wang,Ran Song,Yan Shen,Yang Sun,Yanhong Gu,Yanhong Gu,Yongqian Shu,Qiang Xu +8 more
TL;DR: It is suggested that curcumin may serve as a potent agent for curing human liposarcoma via targeting SERCA2, the most common soft tissue sarcoma through interacting with sarcoplasmic/endoplasic reticulum Ca2+-ATPase 2.
Journal ArticleDOI
G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation
Cheryl de Valliere,Yu Wang,Jyrki J. Eloranta,Solange Vidal,Ieuan Clay,Marianne R. Spalinger,Irina Tcymbarevich,Anne Terhalle,Marie-Gabrielle Ludwig,Thomas Suply,Michael Fried,Gerd A. Kullak-Ublick,Isabelle Frey-Wagner,Michael Scharl,Klaus Seuwen,Carsten A. Wagner,Gerhard Rogler +16 more
TL;DR: A pathophysiological role for pH-sensing receptor OGR1 during the pathogenesis of mucosal inflammation is indicated, which could be reversed by the presence of NF-&kgr;B inhibitors.
Journal ArticleDOI
Cucurmin, anticancer, & antitumor perspectives: A comprehensive review.
Muhammad Imran,Azmat Ullah,Farhan Saeed,Muhammad Nadeem,Muhammad Umair Arshad,Hafiz Ansar Rasul Suleria +5 more
TL;DR: Current manuscript summarizes most of the recent investigations of cucurmin but still further research should be conducted to explore the role of curcumin to mitigate various cancers.
Journal ArticleDOI
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
Miguel López-Lázaro,Elaine Willmore,Andrew G. Jobson,Kathryn Gilroy,Hannah Curtis,Kay Padget,Caroline A. Austin +6 more
TL;DR: Overall, this work shows that curcumin is capable of inducing topo-DNA complexes in cells with both topo I and topo II and increases the evidence suggesting that this dietary agent has potential to be tested in cancer chemotherapy.
References
More filters
Journal ArticleDOI
Function and activation of NF-kappa B in the immune system.
TL;DR: The inhibition of NF-kappa B activation by antioxidants and specific protease inhibitors may provide a pharmacological basis for interfering with these acute processes in suppressing toxic/septic shock, graft-vs-host reactions, acute inflammatory reactions, severe phase response, and radiation damage.
Journal ArticleDOI
AP-1 as a regulator of cell life and death
Eitan Shaulian,Michael Karin +1 more
TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
Journal Article
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
Ann-Lii Cheng,Hsu Ch,Lin Jk,Hsu Mm,Yunn-Fang Ho,Shen Ts,Ko Jy,Lin Jt,Bor-Ru Lin,Ming-Shiang W,Yu Hs,Shiou-Hwa Jee,Chen Gs,Chen Tm,Chi-An Chen,Lai Mk,Yeong-Shiau Pu,Min-Hsiung Pan,Wang Yj,Tsai Cc,Hsieh Cy +20 more
TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
Journal ArticleDOI
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
TL;DR: A model has been proposed for the cytokine‐induced E‐selectin enhancer that is similar to the stereospecific complex proposed forThe inter‐ feron‐β gene promoter, in which multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery.
Journal ArticleDOI
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.