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Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
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Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro.
Jayaraj Ravindran,Gottumukkala V. Subbaraju,Modukuri V. Ramani,Bokyung Sung,Bharat B. Aggarwal +4 more
TL;DR: Overall the results indicate that the substitution of a hydroxyl group for a methoxy group at the meta positions of the phenyl rings in curcumin significantly enhanced the anti-inflammatory activity, and the removal of phenyl ring at the 7(th) position of the heptadiene back bone and addition of hydroxyphenyl group significantly increased theAnti-proliferative activity ofCurcumin.
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Differential effects of curcumin on vasoactive factors in the diabetic rat heart.
TL;DR: The results indicate that one month of diabetes causes an upregulation of both eNOS and iNOS mRNA levels, and nitrotyrosine and 8-OHdG immunoreactivity in the heart and indicate the importance of tissue microenvironment in the treatment of diabetic complications.
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Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells by targeting beta-catenin-mediated transactivation and cell-cell adhesion pathways.
TL;DR: Curcumin (diferuloylmethane), a natural plant product, possesses such chemopreventive activity that targets multiple signalling pathways in the prevention of colon cancer development.
Journal ArticleDOI
Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes.
TL;DR: It is shown that curcumin suppresses the differentiation agent-dependent activation of hINV gene expression and that an AP1 transcription factor DNA binding site in the hInV gene is required for this regulation.
Journal Article
Curcumin-induced Cell Cycle Arrest and Apoptosis in Human Acute Promyelocytic Leukemia HL-60 Cells via MMP Changes and Caspase-3 Activation
Tzu Wei Tan,Hsin Ru Tsai,Hsu Feng Lu,Hui Lu Lin,Mei Fen Tsou,Yuh Tzy Lin,Huei Yann Tsai,Yuh-Fung Chen,Jing Gung Chung +8 more
TL;DR: The inhibition of caspase-3 activation by z-VAD-fmk (broad-spectrum caspases inhibitor) completely blocked curcumin-induced apoptosis in HL-60 cells.
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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.