Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
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References
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Journal Article
Chemoprevention of 4-Nitroquinoline 1-Oxide-induced Oral Carcinogenesis by Dietary Curcumin and Hesperidin: Comparison with the Protective Effect of β-Carotene
Takuji Tanaka,Hiroki Makita,Masami Ohnishi,Yoshinobu Hirose,Aijin Wang,Hideki Mori,Kumiko Satoh,Akira Hara,Hiroshi Ogawa +8 more
TL;DR: The modifying effects of two natural products, curcumin and hesperidin, given during the initiation and postinitiation phases of oral carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO) were investigated in male F344 rats and compared with that of beta-carotene as discussed by the authors.
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The dietary pigment curcumin reduces endothelial Tissue Factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-κB
Angelika Bierhaus,Youming Zhang,Peter Quehenberger,Thomas Luther,Michael Haase,Martin Müller,Nigel Mackman,Reinhard Ziegler,Peter P. Nawroth +8 more
TL;DR: Investigating the effect of curcumin on the TNF alpha induced expression of endothelial Tissue Factor (TF), the central mediator of coagulation known to be controlled by AP-1 and NF-kappa B found that both, NF- kappa B andAP-1 dependent TF expression, were reduced by cur cumin action.
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Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo.
R Thapliyal,G.B Maru +1 more
TL;DR: Turmeric/curcumin as in the case of isothiocyanate, PEITC, are likely to inhibit activation of carcinogens metabolized by CYP450 isozymes, namely, CYP 1A1, 1A2 and 2B1.
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Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation.
TL;DR: The effect of curcumin on mitochondrial function is analyzed and it is suggested that mitochondria might be a target by whichCurcumin induces apoptosis of tumor cells.
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Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production
TL;DR: In chronic inflammation, cytokines induce the production of nitric oxide that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite and inhibited lipopolysaccharide and interferon-gamma induced nitrite production by mouse peritoneal cells by more than 50% at 2.5-10 microM.