Open AccessJournal Article
Anticancer potential of curcumin: preclinical and clinical studies.
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TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.Abstract:
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indianread more
Citations
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Effect of Curcumin on miRNA Expression in Human Y79 Retinoblastoma Cells
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Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway.
Jong-Rung Tsai,Po-Len Liu,Yung-Hsiang Chen,Shah-Hwa Chou,Yu Jen Cheng,Jhi-Jhu Hwang,Inn-Wen Chong +6 more
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In Vivo Evaluation of Curcumin-loaded Nanoparticles in a A549 Xenograft Mice Model
TL;DR: Results suggest that Cum-NPs are effective to inhibit the growth of human lung cancer with little toxicity to normal tissues, and could provide a clinically useful therapeutic regimen, and thus merit more research to evaluate the feasibility of clinical application.
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Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
Alok Mishra,Rakesh Kumar,Abhishek Tyagi,Indu Kohaar,Suresh Hedau,Alok C. Bharti,Subhodeep Sarker,Dipankar Dey,Daman Saluja,Bhudev C. Das +9 more
TL;DR: A therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers is suggested.
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Diet, MicroRNAs and Prostate Cancer
TL;DR: The role of microRNAs in prostate carcinogenesis is reviewed by summarizing the findings from studies on the effect of dietary agents on miRNA expression and function.
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Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
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TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
Tucker Collins,Margaret Read,Andrew S. Neish,Maryann Z. Whitley,Dimitris Thanos,Tom Maniatis +5 more
TL;DR: A model has been proposed for the cytokine‐induced E‐selectin enhancer that is similar to the stereospecific complex proposed forThe inter‐ feron‐β gene promoter, in which multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery.
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.