Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
Citations
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Patent
Method for stabilization of proteins using non-natural amino acids
David A. Tirrell,Yi Tang +1 more
TL;DR: In this article, a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polyptide is presented.
Book ChapterDOI
Host Antimicrobial Defence Peptides in Human Disease
TL;DR: This chapter has focused on the host contact with microbes, where these host defence peptides are key players and the interplay with commensals and pathogens in relation to antimicrobial peptide expression is discussed.
Journal ArticleDOI
Strategies for antimicrobial peptide coatings on medical devices: a review and regulatory science perspective
Mehdi Kazemzadeh-Narbat,Hao Cheng,Hao Cheng,Hao Cheng,Rosa Chabok,Rosa Chabok,Rosa Chabok,Mario Moises Alvarez,Cesar de la Fuente-Nunez,K. Scott Phillips,Ali Khademhosseini +10 more
TL;DR: An overview of the progress made in this field over the past decade with an emphasis on the local release of AMPs from implant surfaces and immobilization strategies for incorporating these agents into a wide range of medical device materials is provided.
Journal ArticleDOI
Interaction of α-synuclein with biomembranes in Parkinson's disease--role of cardiolipin.
TL;DR: It is asserted that the interaction of αS with a liquid-disordering phospholipid uniquely enriched in mitochondrial membranes, namely cardiolipin (1,3-diphosphatidyl-sn-glycerol, CL), helps target the αS oligomeric complexes intracellularly to mitochondria.
Journal ArticleDOI
Temperature-Dependent Modulation of Porphyromonas gingivalis Lipid A Structure and Interaction with the Innate Host Defenses
Michael A. Curtis,R.S. Percival,Deirdre A. Devine,Richard P. Darveau,Stephen R. Coats,Minnie Rangarajan,Edward Tarelli,Philip Marsh +7 more
TL;DR: Temperature elevation at sites of inflammation in the periodontium may be a significant environmental regulator of the lipid A modification systems of P. gingivalis, which will influence the interaction of this organism with the innate host defense.
References
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Journal ArticleDOI
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