Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
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Journal ArticleDOI
Antimicrobial peptides in toroidal and cylindrical pores
Maja Mihajlovic,Themis Lazaridis +1 more
TL;DR: Observations agree with the prevailing views that alamethicin forms barrel-stave pores whereas melittin forms toroidal pores, using molecular dynamics simulations of the peptides in pre-formed toroidal and cylindrical pores.
Journal ArticleDOI
Proline-rich antimicrobial peptides targeting protein synthesis
Michael Graf,Mario Mardirossian,Fabian Nguyen,A. Carolin Seefeldt,Gilles Guichard,Marco Scocchi,C. Axel Innis,Daniel N. Wilson,Daniel N. Wilson +8 more
TL;DR: Insight into the interactions of PrAMPs with their ribosomal target provides the opportunity to further develop these peptides as novel antimicrobial agents.
Journal ArticleDOI
Investigating the effect of increasing charge density on the hemolytic activity of synthetic antimicrobial polymers.
Zoha M. AL-Badri,Abhigyan Som,Sarah K. Lyon,Christopher F. Nelson,Klaus Nüsslein,Gregory N. Tew +5 more
TL;DR: Increase the number of amine groups on the most hydrophobic polymer reduced its hemolytic activity significantly, and dye leakage experiments on lipid vesicles that mimic bacteria and red blood cell membranes showed a strong correlation with the hemolysis data.
Journal ArticleDOI
Local Photothermal/Photodynamic Synergistic Therapy by Disrupting Bacterial Membrane To Accelerate Reactive Oxygen Species Permeation and Protein Leakage.
Congyang Mao,Congyang Mao,Yiming Xiang,Yiming Xiang,Xiangmei Liu,Yufeng Zheng,Kelvin W.K. Yeung,Zhenduo Cui,Xianjin Yang,Zhaoyang Li,Yanqin Liang,Shengli Zhu,Shuilin Wu,Shuilin Wu +13 more
TL;DR: In vivo results reveal that rapid and effective sterilization is an important process to accelerate wound healing, and the traumas on the rats' backbones heal well within 12 days by PTDT.
Journal ArticleDOI
The design, structures and therapeutic potential of protein epitope mimetics.
TL;DR: This work focuses on the protein epitope mimetic (PEM) approach, where folded 3D structures of peptides and proteins are taken as starting points for the design of synthetic molecules that mimic key epitopes involved in protein-protein and protein-nucleic acid interactions.
References
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Journal ArticleDOI
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