Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
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Posted Content
First Passage Problems in Biology
TL;DR: Applications of stochastic models in biological settings are discussed and reviewed in the context of first passage problems spanning applications to molecular dissociation and selfassembly, molecular search, transcription and translation, cellular mutation and disease, and organismic evolution and population dynamics.
Journal ArticleDOI
Structure, activity and interactions of the cysteine deleted analog of tachyplesin-1 with lipopolysaccharide micelle: Mechanistic insights into outer-membrane permeabilization and endotoxin neutralization.
Rathi Saravanan,Harini Mohanram,Mangesh Joshi,Prerna N. Domadia,Jaume Torres,Christiane Ruedl,Surajit Bhattacharjya +6 more
TL;DR: Atomic resolution structure and interactions of CDT with the outer membrane-LPS could be exploited for developing potent broad spectrum antimicrobial and anti-sepsis agents.
Journal ArticleDOI
When Worlds Collide: Interactions at the Interface between Biological Systems and Synthetic Cationic Conjugated Polyelectrolytes and Oligomers
TL;DR: The cytotoxicity of these materials against mammalian cells and human tissues is discussed to explore the potential applications of the CPEs and OPEs as antiseptics and some unanswered questions about their antimicrobial mechanisms are posed.
Journal ArticleDOI
Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations.
Jarbas M. Resende,Cléria Mendonça Moraes,Cléria Mendonça Moraes,Maura V. Prates,Amary Cesar,Fabio C. L. Almeida,Nathália C.C.R. Mundim,Nathália C.C.R. Mundim,Ana Paula Valente,Marcelo P. Bemquerer,Dorila Piló-Veloso,Burkhard Bechinger +11 more
TL;DR: The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.
Journal ArticleDOI
α 67-106 of bovine hemoglobin: a new family of antimicrobial and angiotensin I-converting enzyme inhibitory peptides
TL;DR: These purified peptides have an antibacterial activity against four bacteria strains: Kocuria luteus A270, Listeria innocua, Escherichia coli, and Staphylococcus aureus with a MIC between 187.1 and 35.2 μM and displayed at the same time ACE inhibitory activity with an IC50 range from 42.55 to 1,095 μM.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Raster3D: photorealistic molecular graphics.
Ethan A. Merritt,David Bacon +1 more
TL;DR: Raster3D is discussed, which is a suite of programs for molecular graphics, which must compromise the quality of rendered images to achieve rendering speeds high enough for useful interactive manipulation of three-dimensional objects.
Journal ArticleDOI
Defensins: antimicrobial peptides of innate immunity.
TL;DR: This review, inspired by a spate of recent studies ofdefensins in human diseases and animal models, focuses on the biological function of defensins.