Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
Citations
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Journal ArticleDOI
Contribution of bacterial outer membrane vesicles to innate bacterial defense
Andrew J. Manning,Meta J. Kuehn +1 more
TL;DR: Data reveal a role for OMVs in contributing to innate bacterial defense by adsorption of antimicrobial peptides and bacteriophage, and conclude that OMV production may be an important factor in neutralizing environmental agents that target the outer membrane of Gram-negative bacteria.
Journal ArticleDOI
Design of Antibacterial Surfaces and Interfaces: Polyelectrolyte Multilayers as a Multifunctional Platform
TL;DR: The dominant strategies for antimicrobial material surface design, including the advantaged and disadvantaged strategies, are reviewed.
Journal ArticleDOI
Peptide-membrane interactions and mechanisms of membrane destruction by amphipathic α-helical antimicrobial peptides
Hiromi Sato,Jimmy B. Feix +1 more
TL;DR: Evidence from a variety of experimental approaches indicates that expansion and thinning of the bilayer are common characteristics during the early stages of antimicrobial peptide-membrane interactions, leading to loss of cytoplasmic membrane integrity and cell death.
Journal ArticleDOI
Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance
Fernanda Guilhelmelli,Nathália Vilela,Patrícia Albuquerque,Lorena da Silveira Derengowski,Ildinete Silva-Pereira,Cynthia Maria Kyaw +5 more
TL;DR: It is shown that several AMPs do not modulate membrane permeability in the minimal lethal concentration, and how pathogens evolve resistance to them is described.
Journal ArticleDOI
Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB‐oprM genes
TL;DR: It is demonstrated that the subpopulation of metabolically active cells in Pseudomonas aeruginosa biofilms is able to adapt to colistin by inducing a specific adaptation mechanism mediated by the pmr operon, as well as an unspecific adaptation mechanismmediated by the mexAB‐oprM genes.
References
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