Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
Citations
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Journal ArticleDOI
Alternatives to antibiotics in poultry feed: molecular perspectives.
Gayatri Suresh,Ratul Kumar Das,Satinder Kaur Brar,Tarek Rouissi,Antonio Avalos Ramirez,Younes Chorfi,Stéphane Godbout +6 more
TL;DR: A molecular perspective on the alternatives to antibiotics that have been proposed till date and their current trends, as well as novel approaches such as development of improved delivery systems are provided.
Journal ArticleDOI
New structures help the modeling of toxic amyloidß ion channels
TL;DR: Modeling based on small Abeta oligomers containing extramembranous N-termini predicts channels with shapes and dimensions consistent with experimentally derived channel structures, which support the hypothesis that small AbETA oligomers can form ion channels.
Journal ArticleDOI
Antimicrobial peptides: promising compounds against pathogenic microorganisms.
TL;DR: This review is focused on antibacterial (against Gram (-) and Gram (+) bacteria) and antifungal peptides, discussing action mode of AMPs, and recent advances in the study of the molecular basis of their anti-microbial activity.
Journal ArticleDOI
Robust antimicrobial compounds and polymers derived from natural resin acids
Jifu Wang,Jifu Wang,Yung Pin Chen,Kejian Yao,Perry A. Wilbon,Wujie Zhang,Lixia Ren,Juhua Zhou,Mitzi Nagarkatti,Chunpeng Wang,Fuxiang Chu,Xiaoming He,Alan W. Decho,Chuanbing Tang +13 more
TL;DR: Novel robust resin acid-derived antimicrobial agents that exhibit excellent antimicrobial activities against a broad spectrum of bacteria with selective lysis of microbial membranes over mammalian membranes are reported.
Journal ArticleDOI
Human Antimicrobial Peptide LL-37 Inhibits Adhesion of Candida albicans by Interacting with Yeast Cell-Wall Carbohydrates
TL;DR: Targeting of cell-wall carbohydrates by LL-37 provides a new strategy to prevent C. albicans infection, and it is found that this tool is a useful, new tool to screen for other C.Albicans components involved in adhesion.
References
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