Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
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A helix-PXXP-helix peptide with antibacterial activity without cytotoxicity against MDRPA-infected mice.
TL;DR: HPA3P2 has the potential to be an effective antibiotic for use against multidrug-resistant bacterial strains and reduces production of pro-inflammatory mediators and correspondingly reduced lung (alveolar) and liver tissue damage.
Journal ArticleDOI
Drosomycin, an essential component of antifungal defence in Drosophila.
TL;DR: Two evolutionary epitopes (α‐ and γ‐patch and the m‐loop have been proposed as putative functional regions of drosomycin for interaction with fungi and parasites, respectively and similarity in sequence, structure and biological activity suggests that drosomecin and some defensin molecules from plants and fungi could originate from a common ancestor.
Journal ArticleDOI
Antimicrobial peptides from Phyllomedusa frogs: from biomolecular diversity to potential nanotechnologic medical applications
Leonardo A. Calderon,Alexandre de Almeida e Silva,Pietro Ciancaglini,Rodrigo G. Stábeli,Rodrigo G. Stábeli +4 more
TL;DR: Novel drugs arising from the identification and analysis of bioactive peptides from South American anuran biodiversity have a promising future role on nanobiotechnology.
Journal ArticleDOI
The coral immune response facilitates protection against microbes during tissue regeneration.
Jeroen A. J. M. van de Water,Tracy D. Ainsworth,William Leggat,David G. Bourne,David G. Bourne,Bette L. Willis,Madeleine J. H. van Oppen +6 more
TL;DR: It is demonstrated that corals exhibit immune responses that support rapid recovery following physical injury, maintain coral microbial homeostasis and prevent bacterial infestation that may compromise coral fitness.
Journal ArticleDOI
The structure-mechanism relationship and mode of actions of antimicrobial peptides: A review
TL;DR: The structure characteristics related with bactericide actions, including peptides constituents, molecular length, molecular charges and so on are reviewed, and the common mode of actions of AMPs raised by researchers are summarized.
References
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