Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
Citations
More filters
Journal ArticleDOI
Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides.
TL;DR: The data suggest that multi-functionalization of a single peptide, which is probably mediated by trans-splicing, could be a new mechanism for the functional diversification of scorpion venom peptides.
Journal ArticleDOI
Nanoparticles of Short Cationic Peptidopolysaccharide Self-Assembled by Hydrogen Bonding with Antibacterial Effect against Multidrug-Resistant Bacteria
Zheng Hou,Yogesh Vikhe Shankar,Yang Liu,Feiqing Ding,Jothy Lachumy Subramanion,Vikashini Ravikumar,Rubí Zamudio-Vázquez,Damien Keogh,Huiwen Lim,Moon Y. F. Tay,Surajit Bhattacharjya,Scott A. Rice,Jian Shi,Hongwei Duan,Xue-Wei Liu,Yuguang Mu,Nguan Soon Tan,Kam Chiu Tam,Kevin Pethe,Mary B. Chan-Park +19 more
TL;DR: A cationic nanoparticle self-assembled from chitosan-graft-oligolysine (CSM5-K5) chains with ultralow molecular weight (1450 Da) that selectively kills bacteria is reported that is comparable to that of the last resort MRSA antibiotic vancomycin.
Journal ArticleDOI
Structure-Activity Studies and Therapeutic Potential of Host Defense Peptides of Human Thrombin
Gopinath Kasetty,Praveen Papareddy,Martina Kalle,Victoria Rydengård,Matthias Mörgelin,Barbara Albiger,Martin Malmsten,Artur Schmidtchen +7 more
TL;DR: The work defines structure-activity relationships of C-terminal host defense peptides of thrombin and delineates a strategy for selecting peptide epitopes of therapeutic interest.
Journal ArticleDOI
New antibiotics from Nature's chemical inventory.
TL;DR: The doom and gloom of antibiotic resistance dominates public perception of this drug class and the world needs new antibiotic molecules to replace the exhausted pipeline and the second 'golden era' is certain to come from Nature's chemical inventory once again.
Journal ArticleDOI
Lights, Camera, Action! Antimicrobial Peptide Mechanisms Imaged in Space and Time
TL;DR: Single-cell, time-resolved imaging assays bring a completely new spatiotemporal dimension to AMP mechanistic studies and provide new insights into the timing, sequence, and spatial distribution of AMP-induced effects on bacterial cells.
References
More filters
Journal ArticleDOI
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
Journal ArticleDOI
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Journal ArticleDOI
Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
Book ChapterDOI
Raster3D: photorealistic molecular graphics.
Ethan A. Merritt,David Bacon +1 more
TL;DR: Raster3D is discussed, which is a suite of programs for molecular graphics, which must compromise the quality of rendered images to achieve rendering speeds high enough for useful interactive manipulation of three-dimensional objects.
Journal ArticleDOI
Defensins: antimicrobial peptides of innate immunity.
TL;DR: This review, inspired by a spate of recent studies ofdefensins in human diseases and animal models, focuses on the biological function of defensins.