Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
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The spin label amino acid TOAC and its uses in studies of peptides: chemical, physicochemical, spectroscopic, and conformational aspects.
TL;DR: Work on the paramagnetic amino acid 2,2,6,6-tetramethyl-N-oxyl-4-amino- 4-carboxylic acid, TOAC, and its applications in studies of peptides and peptide synthesis is reviewed.
Journal ArticleDOI
Identification of Immunity-Related Genes in Ostrinia furnacalis against Entomopathogenic Fungi by RNA-Seq Analysis
TL;DR: This study sequenced and characterized the transcriptome of O. furnacalis larvae infected by B. bassiana and identified 190 potential immunity-related unigenes, which contains putative orthologs for nearly all components of the Toll, Imd, and JAK/STAT pathways.
Journal ArticleDOI
Do birds differentially distribute antimicrobial proteins within clutches of eggs
Matthew D. Shawkey,Karl L. Kosciuch,Mark Liu,Frank C. Rohwer,Elizabeth R. Loos,Jennifer Wang,Steven R. Beissinger +6 more
TL;DR: This work aims to demonstrate the power of data-informed decision-making to improve the quality of life of animals and improve the chances of recovery from infectious disease.
Journal ArticleDOI
Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy.
Derry K. Mercer,Marcelo Der Torrossian Torres,Searle S. Duay,Emma Lovie,Laura Simpson,Maren von Köckritz-Blickwede,Cesar de la Fuente-Nunez,Deborah O'neil,Alfredo M. Angeles-Boza +8 more
TL;DR: What is believed to be the key considerations for AST of AMP are described and it is hoped that this information can better guide the preclinical development of AMp toward becoming a new generation of urgently needed antimicrobials.
Journal ArticleDOI
Simulations of Pore Formation in Lipid Membranes: Reaction Coordinates, Convergence, Hysteresis, and Finite-Size Effects
Neha Awasthi,Jochen S. Hub +1 more
TL;DR: This study provides molecular insights into the critical steps of transmembrane pore formation, and it may guide the development of efficient reaction coordinates for pore Formation.
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