Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
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Journal ArticleDOI
Recent advances and perspectives in the design and development of polymyxins
Francesc Rabanal,Yolanda Cajal +1 more
TL;DR: A novel approach considering the modification of the scaffold of polymyxins to integrate metabolism and detoxification issues into the drug design process is a promising new line to potentially prevent accumulation in the kidneys and reduce nephrotoxicity.
Journal ArticleDOI
Activity of Cecropin A-Melittin Hybrid Peptides against Colistin-Resistant Clinical Strains of Acinetobacter baumannii: Molecular Basis for the Differential Mechanisms of Action
José María Saugar,M.J. Rodríguez-Hernández,Beatriz G. de la Torre,María Eugenia Pachón-Ibáñez,María José Fernández-Reyes,David Andreu,Jerónimo Pachón,Luis Rivas +7 more
TL;DR: The results argue in favor of a possible use of CA-M peptides, and by extension other antimicrobial peptides with similar features, as alternative chemotherapy in colistin-resistant Acinetobacter infections.
Journal ArticleDOI
Structure and dynamics of cationic membrane peptides and proteins: insights from solid-state NMR.
Mei Hong,Yongchao Su +1 more
TL;DR: The central role of guanidinium‐phosphate and guanidine‐water interactions in dictating the structural topology of these cationic molecules in the lipid membrane are indicated, which in turn account for the mechanisms of this functionally diverse class of membrane peptides.
Journal ArticleDOI
Structure and function of papiliocin with antimicrobial and anti-inflammatory activities isolated from the swallowtail butterfly, Papilio xuthus.
Jin-Kyoung Kim,Eun-Jung Lee,Soyoung Shin,Ki-Woong Jeong,Jee-Young Lee,Suyoung Bae,Soohyun Kim,Juneyoung Lee,Seong Ryul Kim,Dong Gun Lee,Jae-Sam Hwang,Yangmee Kim +11 more
TL;DR: It is demonstrated that papiliocin is a potent peptide antibiotic with both anti-inflammatory and antibacterial activities, and the groundwork for future studies of its mechanism of action is laid.
Journal ArticleDOI
Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway.
TL;DR: It is proposed that AP‐induced membrane perturbations change the conformation of OmpU to trigger a DegS‐dependent σE‐activating cascade, and Omp U appears to act as a sensor component in a signal transduction pathway.
References
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Journal ArticleDOI
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
Journal ArticleDOI
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Journal ArticleDOI
Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
Book ChapterDOI
Raster3D: photorealistic molecular graphics.
Ethan A. Merritt,David Bacon +1 more
TL;DR: Raster3D is discussed, which is a suite of programs for molecular graphics, which must compromise the quality of rendered images to achieve rendering speeds high enough for useful interactive manipulation of three-dimensional objects.
Journal ArticleDOI
Defensins: antimicrobial peptides of innate immunity.
TL;DR: This review, inspired by a spate of recent studies ofdefensins in human diseases and animal models, focuses on the biological function of defensins.