Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TLDR
In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.Abstract:
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of antimicrobial peptide activity, their relevance to how peptides damage and kill microorganisms still need to be clarified. Recently, there has been speculation that transmembrane pore formation is not the only mechanism of microbial killing. In fact several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibit protein synthesis or inhibit enzymatic activity. In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented.read more
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Journal ArticleDOI
A Novel Target-Specific, Salt-Resistant Antimicrobial Peptide against the Cariogenic Pathogen Streptococcus mutans
Junni Mai,Junni Mai,Xiao-Lin Tian,Jeffrey W. Gallant,Nadine Merkley,Zakia Biswas,Raymond T. Syvitski,Susan E. Douglas,Susan E. Douglas,Junqi Ling,Yung-Hua Li +10 more
TL;DR: A target-specific, salt-resistant antimicrobial peptide that selectively targeted Streptococcus mutans shows promise for future development as an anticaries agent and confirmed that IMB-2 retained its activity in the presence of physiological or higher salt concentrations.
Journal ArticleDOI
Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo.
Paul Bart Noto,Giovanni Abbadessa,Marco Cassone,George Mateo,Alexis Agelan,John D. Wade,Dóra Szabó,Béla Kocsis,Károly Nagy,Ferenc Rozgonyi,Laszlo Otvos +10 more
TL;DR: The longer and presumably more immunogenic prodrug A3‐APO, injected subcutaneously twice over a 3‐wk period, did not induce any antibody production, indicating the suitability of this peptide or its active metabolite for clinical development.
Journal ArticleDOI
Mucroporin, the First Cationic Host Defense Peptide from the Venom of Lychas mucronatus
TL;DR: Results showed that mucroporin could be considered a potential anti-infective drug, especially for treating antibiotic-resistant pathogens.
Journal ArticleDOI
Antifungal compounds that target fungal membranes: applications in plant disease control
TL;DR: The correct use of antifungals that target fungal membranes could be the basis of a promising strategy to lower applications of synthetic pesticides while lengthening the effective life span of the disease control measure.
Journal ArticleDOI
Membrane selectivity by W-tagging of antimicrobial peptides.
Artur Schmidtchen,Lovisa Ringstad,Gopinath Kasetty,Hiroyasu Mizuno,Mark W. Rutland,Martin Malmsten +5 more
TL;DR: The generality of the high membrane selectivity for other peptides of this type is demonstrated, andReplacing cholesterol with ergosterol results in an increased sensitivity for peptide-induced lysis, in analogy to the antifungal properties of such peptides.
References
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