Journal ArticleDOI
Arsenic-induced oxidative stress and its reversibility
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This review summarizes the literature describing the molecular mechanisms of arsenic-induced oxidative stress, its relevant biomarkers, and its relation to various diseases, including preventive and therapeutic strategies and updates the reader on recent advances in chelation therapy and newer therapeutic strategies suggested to treat arsenic- induced oxidative damage.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2011-07-15. It has received 702 citations till now. The article focuses on the topics: Arsenic biochemistry & Arsenic toxicity.read more
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Toxicity of lead: A review with recent updates.
TL;DR: A comprehensive account of recent updates describing health effects of lead exposure, relevant biomarkers and mechanisms involved in lead toxicity, and updates the readers about recent advances in chelation therapy and newer therapeutic strategies, like nanoencapsulation, to treat lead induced toxic manifestations are provided.
Journal ArticleDOI
The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health Problem
Marisa F. Naujokas,Beth Anderson,Habibul Ahsan,H. Vasken Aposhian,Joseph H. Graziano,Claudia Thompson,William A. Suk +6 more
TL;DR: Testing foods and drinking water for arsenic, including individual private wells, should be a top priority to reduce exposure, particularly for pregnant women and children, given the potential for life-long effects of developmental exposure.
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Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants
TL;DR: A deep understanding of the mechanisms involved in eliciting heavy metals toxicity is provided in order to highlight the necessity for development of strategies to decrease exposure to these metals, as well as to identify substances that contribute significantly to overcome their hazardous effects within the body of living organisms.
Journal ArticleDOI
Redox- and non-redox-metal-induced formation of free radicals and their role in human disease.
TL;DR: Current views regarding the role of redox-active/inactive metal-induced formation of ROS, modifications to biomolecules in human disease such as cancer, cardiovascular disease, metabolic disease, Alzheimer's disease, Parkinson’s disease, renal disease, blood disorders and other disease are summarized.
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Foliar heavy metal uptake, toxicity and detoxification in plants: A comparison of foliar and root metal uptake.
TL;DR: This is the first review regarding biogeochemical behaviour of heavy metals in atmosphere-plant system and summarizes the mechanisms involved in foliar heavy metal uptake, transfer, compartmentation, toxicity and in plant detoxification.
References
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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The pharmacological basis of therapeutics
TL;DR: In this article, 42 authors share the herculean task of reviewing the flood of recent literature on pharmacology and rational use of drugs, under single or dual authorship they contribute the 76 chapters in the 18 sections.
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The biochemistry of apoptosis
TL;DR: The basic components of the death machinery are reviewed, how they interact to regulate apoptosis in a coordinated manner is described, and the main pathways that are used to activate cell death are discussed.
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Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.