Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
Citations
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Nonsteroidal Anti-Inflammatory Drugs and the Heart
Carlo Patrono,Colin Baigent +1 more
TL;DR: The interpretation of the effects of NSAIDs has been greatly enhanced by the availability, for the first time, of large, placebo-controlled trials that aimed to assess the potential for chemoprevention of colorectal cancer by rofecoxib or celecoxib.
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American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan: executive summary
Yehuda Handelsman,Jeffrey I. Mechanick,Lawrence Blonde,George Grunberger,Zachary T. Bloomgarden,George A. Bray,Samuel Dagogo-Jack,Jaime A. Davidson,Daniel Einhorn,Om P. Ganda,Alan J. Garber,Irl B. Hirsch,Edward S. Horton,Faramarz Ismail-Beigi,Paul S. Jellinger,Kenneth L. Jones,Lois Jovanovic,Harold E. Lebovitz,Philip T. Levy,Etie S. Moghissi,Eric A. Orzeck,Aaron I. Vinik,Kathleen Wyne +22 more
TL;DR: AACE Task Force for Developing a Diabetes Comprehensive Care Plan Writing Committee Complete guidelines are available at www.aace.com These are clinical practice guidelines (CPGs) for developing a diabetes mellitus (DM) comprehensive care plan as mentioned in this paper.
Journal ArticleDOI
Associations Between Peripheral Artery Disease and Ischemic Stroke. Implications for Primary and Secondary Prevention
TL;DR: In both primary and secondary prevention settings, PAD indicates a high risk of future events, and the presence of PAD does have implications for current management in both primary or secondary prevention of stroke.
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Women and research on cardiovascular diseases in Europe: a report from the European Heart Health Strategy (EuroHeart) project
TL;DR: The current representation of women in European cardiovascular research has been assessed in the EuroHeart project, focusing on the number and percentage of women enrolled, age of participants, time of follow-up, availability of the analysis of data, and gender-based outcomes.
Journal ArticleDOI
Daily Aspirin Use and Cancer Mortality in a Large US Cohort
TL;DR: Results are consistent with an association between recent daily aspirin use and modestly lower cancer mortality but suggest that any reduction in cancer mortality may be smaller than that observed with long-term aspirin use in the pooled trial analysis.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
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Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.