Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
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TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
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Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy.
Hiroshi Yasuda,Yasumasa Matsuo,Yoshinori Sato,Sun-ichiro Ozawa,Shinya Ishigooka,Masaki Yamashita,Hiroyuki Yamamoto,Fumio Itoh +7 more
TL;DR: After successful endoscopic hemostasis, immediate resumption of antiplatelet therapy with proton-pump inhibitors (PPIs) is recommended to prevent further ischemic events.
Journal ArticleDOI
Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets: S2TOP-BLEED
Nina A. Hilkens,Ale Algra,Hans-Christoph Diener,Johannes B. Reitsma,Philip M.W. Bath,László Csiba,Werner Hacke,L. Jaap Kappelle,Peter J. Koudstaal,Didier Leys,Jean-Louis Mas,Ralph L. Sacco,Pierre Amarenco,Leila Sissani,Jacoba P. Greving +14 more
TL;DR: The S2TOP-BLEED score can be used to estimate 3-year major bleeding risk in patients with a TIA or ischemic stroke who use antiplatelet agents, based on readily available characteristics.
Journal ArticleDOI
Platelet aggregation monitoring with a newly developed quartz crystal microbalance system as an alternative to optical platelet aggregometry
Stefan Sinn,Lothar Müller,Hartmut Drechsel,Michael Wandel,Hinnak Northoff,Gerhard Ziemer,Hans Peter Wendel,Frank K. Gehring +7 more
TL;DR: The QCM sensor was able to detect platelet aggregation in both uncoated and fibrinogen coated sensors, and the measuring curves of aggregation measurements and controls were clearly distinguishable from each other in terms of frequency shifts and kinetics.
Journal ArticleDOI
Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease.
TL;DR: In this article, the role of arachidonic acid (AA) metabolism in cardiovascular health and disease as well as their potential therapeutic implication is reviewed, including the role played by different AA metabolites in the modulation of vascular tone and cardiovascular complications.
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CVD screening in low-risk, asymptomatic adults: clinical trials needed.
TL;DR: It is the opinion that clinical trials of one or more of these novel tests, combined with monitoring of traditional risk factors, are needed in asymptomatic, low-risk populations.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
Journal ArticleDOI
Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.