Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
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TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
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Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion)
Christopher M. Reid,Elsdon Storey,Tien Yin Wong,Tien Yin Wong,Robyn L. Woods,Andrew Tonkin,Jie Jin Wang,Jie Jin Wang,Anthony Kam,Andrew L. Janke,Rowan Essex,Walter P. Abhayaratna,Marc M. Budge +12 more
TL;DR: This study will improve understanding of the mechanisms at the level of brain and vascular structure that underlie the effects of aspirin on cognitive function and prove useful as a tool for the identification of individuals at high risk for the development of cerebrovascular disease and cognitive decline.
Journal ArticleDOI
A practical approach to the metabolic syndrome: review of current concepts and management
TL;DR: The revised ‘ABCDE’ approach incorporates the most recent influential studies into a simple yet thorough algorithm for management of the metabolic syndrome, confirming that diet and exercise continue to be the cornerstone of any metabolic syndrome treatment strategy.
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Black soybean extract can attenuate thrombosis through inhibition of collagen-induced platelet activation.
Keunyoung Kim,Kyung Min Lim,Chae Wook Kim,Hyun Jung Shin,Dae Bang Seo,Sang Jun Lee,Ji Yoon Noh,Ok-Nam Bae,Sue Shin,Jin Ho Chung +9 more
TL;DR: Black soybean can be a novel dietary supplement for the prevention of cardiovascular risks and the improvement of blood circulation, and a potential active ingredient for antiplatelet effects of BB was identified to be adenosine.
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Role of aspirin in the primary prevention of cardiovascular disease in diabetes mellitus: a meta-analysis
TL;DR: The use of aspirin cannot be routinely recommended for primary prevention of cardiovascular events in diabetes, as existing trials were limited by small patient numbers and low cardiovascular event rates.
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Screening and primary prevention of colorectal cancer: a review of sex-specific and site-specific differences.
TL;DR: The intention-to-treat random-effects meta-analysis showed that once-only flexible sigmoidoscopy screening performed on average-risk individuals aged 55 + decreased CRC incidence by 18% and mortality by 28%, but sex-specific results were lacking.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
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Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.