Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
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TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
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Evidence for the prevention and treatment of stroke in dialysis patients.
William G. Herrington,Richard Haynes,Richard Haynes,Natalie Staplin,Jonathan Emberson,Colin Baigent,Martin J Landray +6 more
TL;DR: It is important that reliable information on the prevention and treatment of stroke (and other cardiovascular disease) in dialysis patients is generated by performing large‐scale randomized trials of many current and future treatments.
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The influence of type 2 diabetes on fibrin clot properties in patients with coronary artery disease
Søs Neergaard-Petersen,Anne-Mette Hvas,Steen Dalby Kristensen,Erik Lerkevang Grove,Sanne Bøjet Larsen,Fladia Phoenix,Zeyad Kurdee,Peter J. Grant,Ramzi A. Ajjan +8 more
TL;DR: T2DM is associated with prothrombotic changes in fibrin clot properties in patients with CAD, related to quantitative rather than qualitative changes infibrinogen with a possible role for inflammatory proteins.
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NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies.
TL;DR: The association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of myocardial infarction (MI) is studied, separating non-fatal from fatal events, and summarizing the evidence from both observational studies and randomised controlled trials.
Journal ArticleDOI
Guía de práctica clínica de la ESC para el manejo del infarto agudo de miocardio en pacientes con elevación del segmento ST
Gabriel Steg,Stefan James,Dan Atar,Luigi P. Badano,Carina Blomström Lundqvist,Michael A. Borger,Carlo Di Mario,Kenneth Dickstein,Gregory Ducrocq,Francisco Fernández-Avilés,Anthony H. Gershlick,Pantaleo Giannuzzi,Sigrun Halvorsen,Kurt Huber,Peter Jüni,Adnan Kastrati,Juhani Knuuti,Mattie J. Lenzen,Kenneth W. Mahaffey,Marco Valgimigli,Arnoud W van 't Hof,Petr Widimsky,Doron Zahger,Jeroen J. Bax,Helmut Baumgartner,Claudio Ceconi,Veronica Dean,Christi Deaton,Robert Fagard,Christian Funck-Brentano,David Hasdai,Arno W. Hoes,Paulus Kirchhof,Philippe Kolh,Theresa McDonagh,Cyril Moulin,Bogdan A. Popescu,Zeljko Reiner,Udo Sechtem,Per Anton Sirnes,Michal Tendera,Adam Torbicki,Alec Vahanian,Stephan Windecker,Felicity Astin,Karin Astrom-Olsson,Andrzej Budaj,Peter Clemmensen,Jean-Philippe Collet,Keith A.A. Fox,Ahmet Fuat,Olivija Gustiene,Christian W. Hamm,Petr Kala,Patrizio Lancellotti,Aldo P. Maggioni,Béla Merkely,Franz-Josef Neumann,Massimo F. Piepoli,Frans Van de Werf,Freek W.A. Verheugt,Lars Wallentin +61 more
TL;DR: Autores/Miembros del Grupo de Trabajo: Ph.D.s, MSc, Diputados Unidos, República Checa, Petr Widimsky.
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New insights into the mechanisms of action of aspirin and its use in the prevention and treatment of arterial and venous thromboembolism
TL;DR: The aim of this study was to review the literature with regard to the various mechanisms of the newly discovered effects of aspirin in the prevention of the initiation and development of venous thrombosis, and to suggest that the long-term use of low-dose aspirin is effective not only in the Prevention and treatment of arterial thromBosis but also in thevention of VTE.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
Journal ArticleDOI
Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
Journal ArticleDOI
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.