Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
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TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
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2013 Korean Society of Hypertension guidelines for the management of hypertension. Part II—treatments of hypertension
Jinho Shin,Jeong Bae Park,Kwang-Il Kim,Ju Han Kim,Dong Heon Yang,Wook Bum Pyun,Young Gweon Kim,Gheun-Ho Kim,Shung Chull Chae +8 more
TL;DR: Treatment strategies are provided in accordance with the level of global cardiovascular risk, from lifestyle modification in the lower risk group to more comprehensive treatment in the higher risk group.
Journal ArticleDOI
Diabetes and cardiovascular disease: from evidence to clinical practice - position statement 2014 of Brazilian Diabetes Society.
Marcello Casaccia Bertoluci,Augusto Pimazoni-Netto,Antonio Carlos Pires,Antonio Eduardo Pesaro,Beatriz D'Agord Schaan,Bruno Caramelli,Carisi Anne Polanczyk,Carlos Vicente Serrano Junior,Danielle Menosi Gualandro,Domingos A. Malerbi,Emílio Hideyuki Moriguchi,Flávio A. O. Borelli,João Eduardo Nunes Salles,José Mariani Júnior,Luis Eduardo Paim Rohde,Luis Henrique Santos Canani,Luiz Antonio Machado César,Marcos Antonio Tambascia,Maria Tereza Zanella,Miguel Gus,Rafael Selbach Scheffel,Raul D. Santos +21 more
TL;DR: This Position Statement from the Brazilian Diabetes Society was developed to promote increased awareness in relation to six crucial topics dealing with diabetes and cardiovascular disease: Glicemic Control, Cardiovascular Risk Stratification and Screening Coronary Artery Disease, Treatment of Dyslipidemia, Hypertension, Antiplatelet Therapy and Myocardial Revascularization.
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Aspirin Therapy and Risk of Subdural Hematoma: Meta-analysis of Randomized Clinical Trials
TL;DR: Based on the limited available data, it is uncertain whether aspirin therapy increases the risk of subdural hematoma: the observed 1.6-fold increased risk was not statistically significant.
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Benefits and harms of aspirin desensitization for aspirin-exacerbated respiratory disease: a systematic review and meta-analysis.
Derek K. Chu,Daniel D. Lee,Keith M. Lee,Holger J. Schünemann,Wojciech Szczeklik,Wojciech Szczeklik,John M. Lee +6 more
TL;DR: The objective of this study is to systematically review the efficacy and safety of aspirin desensitization in patients with AERD.
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Comparative Effectiveness of Prestroke Aspirin on Stroke Severity and Outcome
Jong-Moo Park,Kyusik Kang,Yong-Jin Cho,Keun-Sik Hong,Kyung Bok Lee,Tai Hwan Park,Soo Joo Lee,Youngchai Ko,Moon Ku Han,Jun Lee,Jae Kwan Cha,Dae-Hyun Kim,Dong-Eog Kim,Joon-Tae Kim,Jay Chol Choi,Kyung Ho Yu,Byung-Chul Lee,Ji Sung Lee,Juneyoung Lee,Philip B. Gorelick,Hee-Joon Bae +20 more
TL;DR: The effect of prestroke aspirin use on initial severity, hemorrhagic transformation, and functional outcome of ischemic stroke is uncertain.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.