Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
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TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
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Treatment of Diabetes in Older Adults: An Endocrine Society Clinical Practice Guideline
Derek LeRoith,Geert Jan Biessels,Susan S Braithwaite,Susan S Braithwaite,Felipe F. Casanueva,Boris Draznin,Jeffrey B. Halter,Jeffrey B. Halter,Irl B. Hirsch,Marie E. McDonnell,Mark E. Molitch,M. Hassan Murad,Alan J Sinclair +12 more
TL;DR: This guideline is to give guidance to practicing health care providers that will benefit patients with diabetes (both type 1 and type 2), paying particular attention to avoiding unnecessary and/or harmful adverse effects.
Journal ArticleDOI
Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis
Michael G. Silverman,Michael J. Blaha,Harlan M. Krumholz,Matthew J. Budoff,Ron Blankstein,Christopher T. Sibley,Arthur S. Agatston,Roger S. Blumenthal,Khurram Nasir,Khurram Nasir +9 more
TL;DR: Among individuals at the extremes of RF burden, the distribution of CAC is heterogeneous, and the presence of a high CAC burden, even among individuals without RFs, is associated with an elevated event rate, whereas the absence of Cac,even among those with many RF, isassociated with a low event rate.
Journal ArticleDOI
Basic Principles of Platelet Biology and Clinical Implications
TL;DR: An overview of the basic principles of platelet biology is given and currently available antiplatelet agents, as well as those under clinical development, are reviewed.
Journal ArticleDOI
Aspirin in the Chemoprevention of Colorectal Neoplasia: An Overview
Andrew T. Chan,Nadir Arber,John Burn,Whay Kuang Chia,Peter Creighton Elwood,Mark A. Hull,Richard F A Logan,Peter M. Rothwell,Karsten Schrör,John A. Baron +9 more
TL;DR: The case for consideration of long-term aspirin use in CRC prevention is strengthened, as there is a lack of consensus about the balance of risks and benefits associated with long- term aspirin use, particularly in low-risk populations.
Journal ArticleDOI
Japanese Clinical Practice Guideline for Diabetes 2016
Masakazu Haneda,Mitsuhiko Noda,Hideki Origasa,Hiroshi Noto,Daisuke Yabe,Yukihiro Fujita,Atsushi Goto,Tatsuya Kondo,Eiichi Araki +8 more
TL;DR: The current edition of the clinical practice guidelines for diabetes in Japan aims to incorporate new insights and findings, as well as new lines of evidence, in diabetes treatment, and has newly adopted a clinical question (CQ)/question (Q) format, instead of the “statement” format of the earlier editions.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
Journal ArticleDOI
Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
Journal ArticleDOI
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.