Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
Colin Baigent,Lisa Blackwell,Rory Collins,Jonathan Emberson,Jon Godwin,Richard Peto,Julie E. Buring,Charles H. Hennekens,Patricia M. Kearney,Tom W. Meade,Carlo Patrono,Maria Carla Roncaglioni,Alberto Zanchetti +12 more
TLDR
In primary prevention without previous disease, aspirin is of uncertain net value as the reduction in occlusive events needs to be weighed against any increase in major bleeds.About:
This article is published in The Lancet.The article was published on 2009-05-30 and is currently open access. It has received 2954 citations till now. The article focuses on the topics: Stroke & Aspirin.read more
Citations
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Antiplatelet drug resistance: Molecular insights and clinical implications.
Christopher N Floyd,Albert Ferro +1 more
TL;DR: Molecular insights into the mechanisms for aspirin and clopidogrel resistance are presented, with a discussion of their clinical implications.
Journal ArticleDOI
Aspirin in gastrointestinal oncology: new data on an old friend.
TL;DR: Recent evidence demonstrates that aspirin has the potential to be an effective preventive and therapeutic agent in gastrointestinal malignancy and re-awakened interest in the role of aspirin in the primary prevention of cancer and in the treatment of cancer.
European Society of Hypertension Scientific Newsletter: Update on Hypertension Management
TL;DR: In this article, the authors pointed out that sexual dysfunction represents a common condition in the general population placing a major burden on patients' and their sexual partners' quality of life, and that physicians skilled in hypertension management often feel unqualified to deal with sexual problems since adequate training regarding sexuality has not been offered in under- or in postgraduate training.
Journal ArticleDOI
Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients
Kanika Jain,Tarun Tyagi,Kanchi Patell,Yi Xie,Anis John Kadado,Seung Hee Lee,Timur O. Yarovinsky,Jing Du,Janice Hwang,Kathleen A. Martin,Jeffrey M. Testani,Costin N. Ionescu,John Hwa +12 more
TL;DR: Clinically, the results advocate the use of less aggressive antiplatelet therapies for CVD in the elderly population, and report a novel age associated, non-linear redox regulation in platelets in both humans and mice.
Journal ArticleDOI
The cardiovascular polypill in high-risk patients:
Melvin Lafeber,Wilko Spiering,Kavita Singh,Rama K Guggilla,Vinodvenkatesh Patil,Ruth Webster +5 more
TL;DR: The recent development of combination pills containing off-patent medications holds promise for highly affordable and effective treatment and evidence is emerging on the use of this strategy in high-risk populations.
References
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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.
Colin Baigent,Anthony C Keech,Patricia M. Kearney,L Blackwell,Georgina Buck,Christine Pollicino,Adrienne Kirby,T Sourjina,Richard Peto,Rory Collins,R. J. Simes +10 more
TL;DR: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics.
Journal ArticleDOI
Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Lennart Hansson,Alberto Zanchetti,S. George Carruthers,Björn Dahlöf,Dag Elmfeldt,Stevo Julius,Joël Ménard,Karl Heinz Rahn,Hans Wedel,Sten Westerling +9 more
TL;DR: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed.
Journal ArticleDOI
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Paul M. Ridker,Eleanor Danielson,Jacques Genest,Antonio M. Gotto,Wolfgang Koenig,Peter Libby,Alberto J. Lorenzatti,Jean G. MacFadyen,Børge G. Nordestgaard,James Shepherd,James T. Willerson,Robert J. Glynn +11 more
TL;DR: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Journal ArticleDOI
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Gary Whitlock,Sarah Lewington,Paul Sherliker,Robert Clarke,Jonathan Emberson,Jim Halsey,Nawab Qizilbash,Rory Collins,Richard Peto +8 more
TL;DR: Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer, despite cigarette consumption per smoker varying little with BMI.